Epigenetics in Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 195
Special Issue Editor
Special Issue Information
Dear Colleagues,
The IJMS journal is hosting a Special Issue on “Epigenetics in Autoimmune Diseases”.
Autoimmune diseases result from a complex interplay of genetic and epigenetic factors. Although genetics contributes to disease predisposition, recent evidence suggests that epigenetic processes, such as DNA methylation, histone modifications and non-coding RNAs, also play a role in pathology development. Various autoimmune diseases have shown differentially methylated promoter and enhancer regions, indicating their involvement in disease pathogenesis. Histones play a crucial role in compacting DNA, and modifying these proteins can activate or silence gene expression. Non-coding RNAs, such as microRNAs and long non-coding RNAs, regulate gene expression by targeting translation levels and/or forming RNA scaffolds for multiprotein complexes. Environmental factors, such as diet, stress, toxins and infections, can interact with epigenetic factors, leading to the onset or worsening of autoimmune diseases. Studying the relationship between epigenetics and autoimmune diseases may reveal new biomarkers and treatment options.
We welcome original manuscripts and reviews from experts in the field of epigenetic modifications, regulatory factors and mechanisms. We encourage authors to address pathophysiology-related issues, specifically those that address systemic aspects.
Dr. Tibor A. Rauch
Guest Editor
Manuscript Submission Information
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Keywords
- autoimmune disease
- DNA methylation
- histone modifications
- miRNAs
- long non-coding RNAs
- circRNAs
- environmental effects
- epigenome-wide analysis
- DNMT inhibitors
- HDAC inhibitors
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