Pain Chronicity and Relief: From Molecular Basis to Rehabilitation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 25 April 2025 | Viewed by 94
Special Issue Editor
Special Issue Information
Dear Colleagues,
Many studies on animals and humans have demonstrated that physical exercise, especially aerobic exercise, is effective in relieving chronic pain. The phenomenon underlying exercise-induced pain relief is exercise-induced hypoalgesia (EIH), and its effects are well observed in both humans and animals. Studies with laboratory animals suggest that the EIH effect is produced by moderate-intensity running and voluntary running, and modifications in the dorsal horn of the spinal cord, activations of the descending pain suppression system, and the mesocorticolimbic system in the brain may be primary mechanisms in producing the EIH effect. Recent human studies suggest that central sensitization may play important roles in producing EIH effects. A recent, interesting topic in this field is the attempt to explore mechanisms for producing barrier factors to inhibit the EIH effect. Fear associated with pain acts as a barrier factor to the EIH effect, which may be implicated in dysfunction of the reward system and activation of the central nucleus of the amygdala. The purpose of this Special Issue is to update on cellular and molecular mechanisms that induce the EIH effects, and its barrier factors underlining exercise therapy for chronic pain.
Prof. Dr. Katsuya Kami
Guest Editor
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Keywords
- exercise-induced hypoalgesia
- barrier factor
- chronic pain
- neuropathic pain
- spinal cord dorsal horn
- mesocorticolimbic system
- myokine
- descending pain modulatory system
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