New Insights into Hyaluronan in Human Medicine
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 70
Special Issue Editor
Interests: cellular biology, particularly on understanding the molecular mechanisms involved in cell-cell and cell-matrix interactions, as well as the release of extracellular vesicles; exploring above processes within the context of regenerative medicine, with a specific focus on diabetes
Special Issue Information
Dear Colleagues,
Hyaluronan (HA) plays a multifaceted role in various physiological and pathological processes, including the regulation of cell growth, migration, and survival. The biological activities of HA are influenced by its molecular mass, turnover rate, and interactions with specific receptors, yet the precise mechanisms through which HA orchestrates these functions remain partially unclear. Recent metabolomics studies have uncovered novel roles for HA in cellular metabolism, highlighting its ability to modulate cellular behavior by reprogramming metabolism in response to HA production. Notably, HA overproduction in adipose tissue has been associated with improved glucose metabolism, suggesting the complex roles played by HA in metabolic diseases such as obesity and type 2 diabetes. Additionally, HA degradation has been linked to tumor cell migration and glucose uptake. This Special Issue aims to explore the diverse roles of HA in various diseases, providing new insights into its complex biological functions and potential use of HA in therapeutic applications and clinical practice.
Dr. Monica Salamone
Guest Editor
Manuscript Submission Information
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Keywords
- hyaluronan
- regenerative medicine
- inflammation
- cancer therapy
- metabolomics
- hyaluronidases
- cell–matrix interaction
- glucose metabolism
- pathological processes
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