Apoptosis and Autophagy in Cancer Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 33
Special Issue Editors
Interests: microRNAs; biomarkers; apoptosis; cancer profiling; immunology
Special Issues, Collections and Topics in MDPI journals
Interests: molecular pathology; targeted therapies; biomarkers; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue will cover apoptosis and autophagy in cancer biology, focusing on the regulatory role of coding and noncoding genomes in these processes. Apoptosis, a mechanism of programmed cell death, is essential for cell homeostasis but is often disrupted in cancer cells, allowing them to escape death and grow uncontrollably. Autophagy, the pathway of degradation and recycling, plays a dual role in cancer: it acts as a tumour suppressor or a survival mechanism in stressed cellular situations. Both coding genes and noncoding genomic elements, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and other regulatory RNAs, are involved in the complex regulation of these processes, which significantly impact cancer’s development, progression, and therapeutic response.
Papers are welcome that are related to the following sections:
1. Regulatory mechanisms.
This section will focus on the complex regulatory networks that regulate apoptosis and autophagy in cancer, exploring the role of coding and noncoding genomic elements.
2. Therapeutic implications.
This section presents studies investigating apoptosis- and autophagy-based therapeutic strategies that target both encoded and noncoding genomic targets.
3. Mechanisms of resistance.
This section examines how changes in the coding and noncoding regions of the genome contribute to the ability of cancer cells to avoid apoptosis and autophagy, leading to resistance to therapy.
4. Biomarker discovery.
In this section, we encourage research to identify genomic biomarkers associated with apoptosis and autophagy pathways in cancer, including both encoded and noncoding genomic elements that help to diagnose, prognosis, or predict response to treatment.
5. Double role in the tumor microenvironment.
This section investigates the role of apoptosis and autophagy in the tumour microenvironment, including the impact of coding and noncoding genomes on cell–cell interactions, immune response, and metastatic behaviour.
This Special Issue will provide a comprehensive overview of the impact of coding and noncoding genes on apoptosis and autophagy. It will advance cancer research by providing innovative insights into the mechanisms of cell death and survival. We invite original research, reviews, and perspectives that shed light on these dual cellular processes as potential targets for cancer therapy.
Prof. Dr. Ioana Berindan-Neagoe
Dr. Radu Pirlog
Guest Editors
Manuscript Submission Information
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Keywords
- apoptosis
- autophagy
- cancer biology
- coding and noncoding genomes
- cell homeostasis
- therapeutic strategies
- cell death and survival
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