Molecular Research in Sarcoidosis and Granuloma
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 252
Special Issue Editor
Interests: sarcoid; asthma and pulmonary; hypertension; sarcoidosis; granuloma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sarcoidosis is a prototypic chronic granulomatous inflammatory disorder that predominantly affects the lung. In the United States (between 1988 and 2007), there has been a 3% annual increase in sarcoidosis associated mortality. This disease in the United States is more prevalent in African Americans than in Caucasians. The etiology is unclear, but it appears that certain inciting factors (such as infections, organic dusts, carbon nanotubes, etc.) trigger dysregulated immunity, mediated mostly by alveolar macrophages, which leads to granuloma formation.
Initial formation of the granuloma involves the release of a large repertoire of pro-inflammatory mediators designed to recruit neutrophils and other cells into the area. If neutrophils cannot destroy the substance, it is phagocytized by macrophages which release additional pro-inflammatory cytokines and chemokines. Failure of macrophages to destroy the substance within the granuloma results in a chronic inflammatory pulmonary condition that can have significant morbidity.
Even though sarcoidosis mostly affects the lung, for this series collection on sarcoidosis, we are inviting original research articles that encompass other types of granulomas affecting other organs in sarcoidosis. Research at the molecular level is highly encouraged.
Dr. Anagha Malur
Guest Editor
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Keywords
- granulomas
- inflammation
- lymphocytes
- macrophages
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