Biophysical Perspectives on Bone Physiology and Pathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: 30 December 2024 | Viewed by 113
Special Issue Editors
Interests: Ca2+ signaling; membrane protein; receptor; ion channel; drug discovery; bone; chondrocyte; energy homeostasis
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue, which aims to present the latest advancements in bone formation, development, and growth.
The growth plate cartilage plays a pivotal role in longitudinal growth through the process of bone formation. This cartilage undergoes a sequence of differentiation stages, transitioning from stem cells to resting chondrocytes, then to proliferating chondrocytes, and finally to hypertrophic chondrocytes. At the end of the growth plate, hypertrophic chondrocytes are either replaced by bone tissue or differentiated into osteoblasts, which are crucial for bone formation. Osteoblasts also stimulate osteoclast activity, and the cooperation of osteoblasts and osteoclasts is essential for the formation of healthy bone tissue. This process, encompassing ossification and longitudinal bone growth, is vital for skeletal development. Disruptions at any stage of this process can lead to growth impairments and/or bone deformities. Consequently, research into bone formation and growth is fundamental for developing treatments for bone disorders. Recent studies have unveiled novel intracellular signaling pathways that regulate bone formation and elongation and have provided insights into the molecular basis of bone diseases arising from disruptions in these pathways.
This Special Issue welcomes original research articles and reviews focusing on the physiology and pathology of bone formation, development, and growth. Topics of interest include, but are not limited to, the functions of chondrocytes, osteoblasts, and osteoclasts.
Dr. Atsuhiko Ichimura
Dr. Yohei Ueda
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- bone formation
- bone disorders
- physiology
- pathology
- stem cells
- osteoblasts
- osteoclasts
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