Germline Mutations, Somatic Mutations and Their Phenotypic Effects in Humans and Animals
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 15
Special Issue Editor
Interests: cell doping; gene doping; gene editing; gene silencing; gene therapy
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Special Issue Information
Dear Colleagues,
Germline mutations may occur in reproductive cells (eggs and sperm), known as gametes or sex cells. These mutations, which are passed on to future generations and are present in all offspring cells, can lead to hereditary diseases, cancer, and sports performance enhancement. Somatic mutations occur individually in somatic cells and are not passed on to future generations. These mutations can be caused by errors in DNA replication or exposure to environmental toxins and can cause several types of cancers. Although the mutational process in germline and somatic cells is considered common, the mutation rate is particularly low in spermatogonia, suggesting that the lineage of germ cells has a mechanism for maintaining a low mutation rate.
In this Special Issue, we discuss germline and somatic mutations that occur in all animals, including humans, and summarize their developmental mechanisms and effects on phenotypes. This Special Issue welcomes original articles and reviews, addressing the search for new insights in this field.
Dr. Teruaki Tozaki
Guest Editor
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Keywords
- germline mutations
- somatic mutations
- genetic disorders
- single nucleotide variant (SNV)
- insertion
- deletion
- copy number variation (CNV)
- structure variation (SV)
- sports enhancement
- cancer
- melanoma
- coat color
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