Host Responses to Virus Infection
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 75
Special Issue Editors
Interests: interferon signaling; viral infection; T cell receptor
Special Issue Information
Dear Colleagues,
Virus infections, especially those caused by unknown pathogens, pose a significant threat to our society. Learning from the COVID-19 pandemic, we aim to understand how to cope with emerging infectious diseases. This discussion focuses on the responses of host cells to viral infections, particularly the role of cytokines. While cytokines can have beneficial effects in preventing viral spread and expelling the virus, inappropriate responses can lead to devastating consequences for the host. Type I interferons (IFNs), such as IFN-alpha and IFN-beta, type II IFN (IFN-gamma), and other cytokines play crucial roles in activating the intracellular molecules that inhibit viral replication within the cells. Additionally, these cytokines are secreted extracellularly to recruit immune cells. Proper immunological responses to viruses are regulated not only by primary immune cells, such as dendritic cells, T cells, and B cells, but also by the local cytokine environment created by infected cells and immune cells. We will discuss how to harness host reactions to viral infections for effective vaccination and possible preventive measures against fatal cytokine storms.
This Special Issue seeks manuscripts that enhance our understanding of host reactions to viral infections and contribute to the development of efficacious vaccination methods and potential preventive measures against fatal cytokine storms.
Dr. Hideki Hayashi
Dr. Yoshinao Kubo
Guest Editors
Manuscript Submission Information
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Keywords
- viral infection
- host reactions
- interferon alpha and beta
- interferon gamma
- cytokines
- vaccine
- cytokine storm
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