Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 January 2025 | Viewed by 326
Special Issue Editor
2. Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Interests: breast cancer; pancreatic cancer; non-small cell lung cancer; neuroinflammation; NLRP3; microRNA; inflammasome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug resistance to cancer remains a major obstacle in clinical practice, which is one of the leading causes of treatment failure and cancer-related mortality. The reduced effectiveness of anticancer drugs is a multifaceted phenomenon that can arise from genetic, epigenetic, and microenvironmental factors. Various molecular mechanisms, including genetic alterations, epigenetic changes, tumor heterogeneity, drug inactivation, activation of alternate signaling pathways, reduced intracellular drug accumulation/increased drug efflux, the tumor microenvironment, and tumor plasticity, have been discovered and extensively discussed. Overcoming drug resistance in cancer requires a comprehensive approach, addressing the development of novel therapeutic strategies such as identifying biomarkers that can predict drug response and resistance, identifying new targets, developing new targeted drugs, using combination therapies targeting multiple signaling pathways, modulating the tumor microenvironment, and applying nanotechnology to enhance drug delivery.
We are delighted to invite you to contribute to this Special Issue of the International Journal of Molecular Sciences (IJMS), entitled “Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer”. This Special Issue aims to address the critical challenges posed by drug resistance in cancer treatment and explore innovative strategies to overcome this barrier. Research areas may include, but are not limited to, the following:
- Insights into molecular mechanism involved in drug resistance in cancer;
- Crosstalk between drug resistance and cancer treatment;
- Strategies for improving the efficacy of current FDA-approved anticancer drugs;
- Development of new drugs against drug resistance in cancer;
- Combination therapy strategies against tumor resistance;
- Preclinical and clinical studies on overcoming drug resistance in various cancer types;
- Approaches that can improve prognosis and the quality of cancer patient’s life during cancer treatment.
We look forward to receiving your valuable contributions that will help to advance this critical field of research.
Dr. Inamul Haque
Guest Editor
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Keywords
- drug resistance
- cancer therapy
- targeted therapy
- nanotechnology
- tumor microenvironment
- signaling pathway
- immunotherapy
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