Urothelial Cancer: From Translational Medicine to Recent Innovations in Therapeutic Management
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 20
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bladder and upper-way urothelial cancer represent a significant global health burden (12th most commonly diagnosed cancer worldwide) being characterized by high recurrence rates post-initial treatment. Moreover, gender differences in urothelial cancer prevalence and response to therapy emphasize the importance of personalized treatment strategies. Furthermore, the recent advances in the radiological field highlight the importance of accurate staging that may become crucial in identifying the optimal treatment (e.g., transurethral resection vs. radical cystectomy vs. bladder preservation) within the scenario of very personalized medicine. Many factors, including the patient, radiobiology, and radiation physics, influence the results of cancer radiotherapy. Recent advances in novel drugs, molecular techniques, and outcome prediction models have increased the importance of molecular bladder cancer research. Surgery still remains the backbone for the radical treatment of urothelial cancer, which is characterized by several different mini-invasive (e.g., robot-assisted) or invasive approaches, even if the optimal choice is still under investigation. On the other hand, some patients may be suitable for more conservative therapies, maintaining the same chance of being cured. The intersection of molecular science and bladder surgery offers great promise for patient-centered surgical care. Bladder cancer is actually potentially curable through trimodal therapy, allowing organ preservation using systemic drugs in combination with radiation therapy. Finally, The treatment of patients with advanced disease is rapidly changing as immunotherapy using checkpoint inhibitors, targeted therapies, and antibody-drug couplings have become options for patients at certain different disease stages. Understanding of the molecular biology and genetics associated with bladder cancer is increasing, and the diagnostic and therapeutic approaches to bladder cancer are changing. Original articles and comprehensive reviews on the topic that focus on molecular research are warmly welcomed.
Dr. Alessio Bruni
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- urothelial cancer
- bladder cancer
- radiation therapy
- trimodality approach
- immunotherapy
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
