The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 178
Special Issue Editor
Interests: stem cells; cell senescence; stem cell differentiation; gene expression; epigenetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Mesenchymal Stem Cells (MSCs) are multipotent stromal cells with the unique ability to differentiate into various cell types, which can be strongly influenced by epigenetic changes and environmental stimuli. This ability makes MSCs an invaluable resource for repairing damaged tissues and organs in vitro and in vivo. More than 800 clinical trials on humans are related to MSCs as therapy, especially for bone and cartilage defects or neurological disorders. Moreover, MSCs have important immunomodulatory properties, positively influencing the immune system response. Although the exact mechanisms underlying MSC immunomodulation are not entirely understood, it is known that they can move from the resident niche and secrete several soluble factors. Elucidating these mechanisms, enhancing migration, adhesion, and paracrine trophic factor secretion, could pave the way for new therapeutic approaches in regenerative medicine. This Special Issue will include a selection of research papers and reviews to develop accurate strategies for their efficient use in cellular therapy. In addition, clinical studies evaluating epigenetics and stem cells in regenerative medicine are suitable for submission to this Special Issue.
This Special Issue is supervised by Dr. Sara Cruciani and assisted by our Topical Advisory Panel Member, Dr. Giuseppe Garroni (University of Sassari). We welcome your submission.
Dr. Sara Cruciani
Guest Editor
Manuscript Submission Information
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Keywords
- stem cells
- differentiation
- cell therapy
- tissue regeneration
- cell mechanisms
- regenerative medicine
- immunomodulation
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