Advancement in Novel Multidrug Resistant (MDR) Transport Proteins
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 231
Special Issue Editor
Interests: multidrug resistance proteins; small-molecule inhibitors; drug-protein interactions; MDR protein; molecular characterization; drug resistance mechanisms; design of Inhibitors
Special Issue Information
Dear Colleagues,
Multidrug resistance (MDR) proteins play a key role in making it difficult to treat diseases like cancer, infections, and neurological disorders. Proteins such as P-glycoprotein (P-gp) and ATP-binding cassette (ABC) transporters create major obstacles by actively removing therapeutic drugs from cells, reducing their effectiveness. This special issue will provide a thorough look into recent research on the biology and function of MDR proteins. By studying the molecular details of these transporters, scientists can develop new strategies to block their activity and combat drug resistance. Topics will include studies on protein structures, identification of new inhibitors, how drugs interact with these proteins, and the clinical effects of targeting MDR proteins in treatments.
The Topic will also discuss the latest methods for identifying and analyzing MDR proteins, emphasizing the importance of high-resolution structural studies and functional tests. Understanding how these proteins work—such as how they pump drugs out of cells, affect metabolism, and interact with cell signaling pathways—is essential for developing targeted treatments. The special issue will feature recent discoveries about how MDR proteins function at the molecular level and how they interact with other components in the cell. These findings will help explain their role in drug resistance. By fostering collaboration among researchers, clinicians, and industry experts, this collection seeks to address the challenges of MDR proteins and inspire further research into understanding their mechanisms and developing better therapies.
Dr. Sven Marcel Stefan
Guest Editor
Manuscript Submission Information
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Keywords
- multidrug resistance proteins
- small-molecule inhibitors
- drug-protein interactions
- MDR protein
- molecular characterization
- drug resistance mechanisms
- design of Inhibitors
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