Decoding Cancer's Immune Escape: Insights into MHC Class I Antigen Presentation Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 506
Special Issue Editors
Interests: prostate cancer; immunology; microenvironment; immunotherapy; histology; complexity; modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antigen Processing and Presentation Machinery (APM) is a complex system that plays a critical role in the immune system's ability to detect and respond to foreign molecules, such as those from pathogens or cancer cells. This machinery is responsible for processing and presenting antigens to T cells, which play a key role in the immune response. Cancer cells are able to evade the immune system by altering the way they present antigens, or by downregulating the expression of MHC molecules on their surface. This can make it difficult for T cells to recognize and attack the cancer cells. One way that cancer cells can evade the immune system is through a process called "immunoediting." This process involves the selection of cancer cells that are able to evade the immune response, leading to the development of "immunoedited" tumors that are resistant to attack by T cells. In addition, some cancer cells can downregulate the expression of MHC class I molecules on their surface, making them invisible to T cells. This is known as "MHC loss" and is a common mechanism of immune evasion in human cancers. Some cancer types have been found to have a high frequency of mutations and defects in APM, making them more susceptible to immune system detection, such as melanoma and colorectal cancer. In other types of cancer, such as ovarian cancer, and certain types of lung cancer, the immune system is often suppressed and unable to recognize and attack the cancer cells effectively. Understanding the mechanisms by which cancer cells evade the immune system through alterations in APM can aid in developing new cancer immunotherapies.
The Special Issue will contain a collection of manuscripts focused on APM and cancer research, encompassing investigations into its development, progression, diagnosis, risk assessment, and prognosis. These manuscripts will place particular emphasis on the underlying molecular features of the neoplastic disease, with the aim of quickly developing more effective therapeutic approaches. The Special Issue will welcome the latest research articles and reviews that clarify concepts, interpret experimental data, suggest specific experiments, and organize the vast body of knowledge on prostate cancer.
Prof. Dr. Fabio Grizzi
Prof. Dr. Maurizio Chiriva-Internati
Guest Editors
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Keywords
- cancer
- antigen processing and presentation machinery
- molecular mechanisms
- diagnosis
- prognosis
- modelling
- therapy
- microenvironment
- immuno-oncology
- bioinformatics
- imaging
- spatial genomics
- spatial transcriptomic
- tumor complexity
- biomarkers
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