In Vitro and In Vivo Models of Cancer Progression
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 December 2024 | Viewed by 260
Special Issue Editors
2. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Interests: pancreas adenocarcinoma; hematological malignancies; lymphoma; CREB; TRAIL; apoptosis; caspase enzymes; extracellular vesicles; transmission electron microscopy
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2. Department of Medicine and Aging Sciences, Section of Biomorphology, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: in vitro and in vivo models of cancer progression; immunohistochemistry; immunocytochemistry; molecular biology; immunology; light and fluorescence imaging, biochemistry; -omics
Special Issue Information
Dear Colleagues,
We are delighted to announce a call for submissions to this Special Issue of the International Journal of Molecular Sciences on the topic of In Vitro and In Vivo Models of Cancer Progression.
Since the first investigations on malignant transformation induced by the overexpression of putative oncogenes in NIH 3T3 cells, more and more sophisticated approaches have evolved, along with our appreciation of the complexity of cancer progression and the availability of novel technologies. In vitro 2D cultures and in vivo growth in immunocompromised mice of established, well-characterized cancer cell lines provide feasible proof-of-principle models for pathway dissection and drug testing. This is aided by the availability of a range of techniques for the targeted genetic manipulation of cells and animals. Specific transgenic mice have been generated that undergo spontaneous tumour development or provide a humanized immunocompetent milieu. In a continuous effort to better represent tumour heterogeneity, and the essential role played by tissue architecture and the microenvironment, the use of 3D spheroid and organoid cultures and patient-derived cancer tissues have been developed alongside. Patient-derived xenografts (PDX) have been established to provide clinically relevant models for personalized medicine. Patient-derived organoids (PDO) and organs-on-a-chip recapitulate complexity in an actionable animal-free context. Multi-omics characterization and high-content analysis add in-depth knowledge for drug discovery/repositioning and systems biology.
We encourage the submission of both original research articles and topical reviews that focus on modelling cancer progression through in vitro and in vivo approaches for the advancement of our understanding of tumour biology and translation to the clinic.
Prof. Dr. Roberta Di Pietro
Dr. Emanuela Guerra
Guest Editors
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Keywords
- tumour biology
- cancer progression
- cancer microenvironment
- in vitro and in vivo models
- patient-derived xenografts
- patient-derived organoids
- organs-on-a-chip
- multi-omics
- drug discovery
- drug repositioning
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