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Molecular Mechanisms of Platelet-Related Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 312

Special Issue Editors


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Guest Editor
Laboratoire d'hématologie - Centre de Référence des Pathologies Plaquettaires, Hôpital cardiologique du Haut-Lévêque - CHU de Bordeaux, Av. de Magelan, 33604 Pessac, France
Interests: coagulation; platelets; haemostasis; inherited platelet disorders; Glanzmann thrombasthenia disease

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Guest Editor
Synapse Research Institute, Kon. Emmaplein 7, 6214 AC Maastricht, The Netherlands
Interests: coagulation; platelets; haemostasis; omics; signal transduction; thrombo-inflammation; thrombosis; vessel wall
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Guest Editor
Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, 3000 Leuven, Belgium
Interests: platelets; megakaryocytes; transcriptomics; whole genome/exome sequencing; inherited bleeding platelet and thrombotic disorders; megakaryopoiesis; thrombopoiesis

Special Issue Information

Dear Colleagues,

Platelets are disc-shaped, anucleate blood cells derived from megakaryocytes. Platelets need to circulate at certain counts and have a certain capability to activate and form aggregates for proper haemostasis and vascular integrity. Activated platelets furthermore contribute to local inflammation and thrombosis. Disorders in platelet count or function can have a genetic, acquired or indirect reason, although in many patients with a bleeding tendency the cause of a platelet disorder is still unknown. Human patient and mouse knockout studies have indicated that hundreds of platelet-expressed proteins are required for normal function. These proteins include multiple receptors (for thrombin, ADP, ATP, collagen, thromboxane and many more), signalling proteins, vesicular components and even transcription factors. Via regulated surface exposure or via the activation of membrane proteins or phospholipids, platelets can interact with nearby blood cells, vascular components or the coagulation system. Aberrant or pathophysiological interactions of platelets with immune or other cells may extend the consequences of platelet dysfunction to many other diseases. Platelet-related disorders are thus considered not only as a cause of bleeding, but also as a factor in thrombosis, inflammation, infection or neoplasia. However, for many expressed genes and proteins the link to normal platelet function is still unclear.

This Special Issue will cover a selection of game-changing research papers and review articles on the possible (new) causes and consequences of quantitative or qualitative platelet disorders. Papers with a molecular orientation will be considered for this Special Issue, but clinical papers are discouraged by International Journal of Molecular Sciences.

Dr. Mathieu Fiore
Prof. Dr. Johan W. M. Heemskerk
Prof. Dr. Kathleen Freson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • bleeding
  • coagulation
  • haemostasis
  • platelets
  • platelet-related disorders
  • signal transduction
  • thrombocytopenia
  • von Willebrand factor

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Published Papers

There is no accepted submissions to this special issue at this moment.
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