The Role of Histones in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 210
Special Issue Editor
Interests: histones; sepsis; inflammation; proteolysis; cytokines and growth factors; translational research; matrix metalloproteinases; thromboinflammation; clinical biochemistry; platelets; neutrophils; macrophages; laboratory medicine; laboratory tests; monocyte distribution width; monocyte heterogeneity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The roles of histones have changed significantly since their discovery.
Histones were initially known as intranuclear positively charged proteins involved in the organization of eukaryotic DNA into chromatin and gene transcription. Their post-translational modifications are crucial epigenetic mechanisms regulating various biological events, whose dysregulation is implied in various human diseases.
Moreover, histones have received recent relevant attention for their growing extranuclear and extracellular roles. Histones are mainly found extracellularly due to their release during cell death processes, including the extrusion of extracellular traps. Several functions have been proposed for extracellular histones, ranging from antimicrobial effects attempting to defend the host from pathogen invasion to damage-associated molecular pattern molecules with potentially self-detrimental, inflammatory, and pro-coagulant effects when circulating at high levels.
On these bases, histones have the potential to become both biomarkers and therapeutic targets in a wide variety of pathological conditions, from inflammo-thrombosis-associated diseases to cancer.
This Special Issue aims to cover the current advances in the knowledge of the beneficial and harmful roles of histones and their possible use as biomarkers and therapeutic targets.
Dr. Daniela Ligi
Guest Editor
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Keywords
- histones
- circulating histones
- nucleosomes
- human health and disease
- post-translational modifications
- gene transcription
- damage-associated molecular pattern proteins
- ETosis
- biomolecular markers
- therapeutic targets
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