Zebrafish in the Investigation of Organelle Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 July 2024) | Viewed by 162
Special Issue Editor
Interests: animal and cellular model of human disease; thyroid hormone signalling; infertility; EDC
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the last decade, several human diseases relying on the dysfunction of a single organelle have been identified. Their investigation requires the development of in vivo models that will allow not simply the reproduction of the main aspect of the human disease and the molecular characterization of the observed dysfunction but also what is happening at the single-cell level via cellular tracing. Zebrafish, due to their transparent embryos and the availability of strains that also have this characteristic in adulthood, offer a unique opportunity to investigate both. Furthermore, more than 70% of the genes contributing to human diseases are retrieved in zebrafish, and their genetic manipulation fully recapitulates the main aspects and mechanisms of human diseases.
This Special Issue will be dedicated to papers showing zebrafish models of human diseases involving organelles (mitochondrion, lysosome, Golgi, etc.).
Dr. Concetta Ambrosino
Guest Editor
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Keywords
- zebrafish models
- organelle diseases
- mitochondrion
- lysosome
- Golgi
- human diseases
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