Advances in Kidney Transplantation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 52
Special Issue Editor
Special Issue Information
Dear Colleagues,
Kidney transplantation (KTX) is considered the best treatment for end-stage renal disease (ESRD). Despite excellent short-term results in KTX, organ survival has not changed significantly over the past decades, with a significant number of transplants failing within 10–15 years. This is accompanied by several unmet medical challenges. Chronic rejection, particularly antibody-mediated rejection, is a significant contributor to up to 50% of late graft loss. However, we still face diagnostic challenges as biopsy-based diagnostics are limited by non-specific lesions with significant overlap in diagnostic categories. Tailoring immunosuppression is also challenging, as immunosuppressive drugs are essential to prevent rejection but are associated with serious side effects, including increased risk of infection, cancer, and metabolic complications such as diabetes and cardiovascular disease. Some infections, including BK virus nephropathy, can lead to early graft loss despite current attempts to reduce IS to control BK infection.
This Special Issue dedicated to Advances in Kidney Transplantation will cover the full spectrum of research questions related to diagnostic and prognostic challenges in kidney transplantation, including treatment, with a focus on unresolved medical issues. This includes, but is not limited to, chronic rejection, BKVAN, immunosuppressive regimens, and selection of kidney transplant candidates. Original research, mini and full reviews, and commentaries are all welcome. IJMS is a journal of molecular science, so submitted clinical studies should cover biomolecular findings and their role in unresolved questions in renal transplantation.
Dr. Zeljko Kikic
Guest Editor
Manuscript Submission Information
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Keywords
- chronic rejection
- antibody-mediated rejection
- immunosuppression
- BK virus nephropathy (BKVAN)
- diagnostic challenges
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