Cutting-Edge Advances in Transcriptional Therapy and Nucleic Acid-Based Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 10 July 2025 | Viewed by 17
Special Issue Editor
Interests: genomics; transcriptomics; colorectal cancer; molecular biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue explores cutting-edge advances in transcriptional therapy and nucleic acid-based therapeutics, focusing on their potential to revolutionize precision medicine. Transcriptional therapy addresses genetic and epigenetic disorders by modulating gene expression through tools like CRISPR-based gene editing, transcription activator-like effectors (TALEs), and small molecules. Nucleic acid-based therapeutics, including antisense oligonucleotides (ASOs), siRNAs, peptide nucleic acids (PNAs), and aptamers, offer innovative treatments by precisely targeting RNA (both coding and non-coding) or DNA sequences.
This Special Issue emphasizes interdisciplinary research, relating to topics such as improved delivery systems, enhanced stability and efficacy, and strategies to minimize off-target effects. These applications hold significant promise for the treatment of complex diseases, including cancer, autoimmune disorders, metabolic syndrome, and obesity. This collection offers a comprehensive overview of recent advances in transcriptional therapy and nucleic acid-based therapeutics, from identifying molecular targets to integrating fundamental research with therapeutic innovation, aiming to accelerate their translation into clinical applications.
Dr. Vincenza Barresi
Guest Editor
Manuscript Submission Information
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Keywords
- antisense oligonucleotides (ASOs)
- siRNAs
- peptide nucleic acids (PNAs)
- aptamers
- transcriptional therapy
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