Drug Design and Discovery for the Therapy of Infectious Tropical Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067).
Deadline for manuscript submissions: closed (10 March 2024)
Special Issue Editor
Interests: medicinal chemistry; natural products; multi-component reactions; metal-based drugs; antibiotics and antimycotics; anticancer drugs; antiparasitic drugs; antiviral drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infectious tropical diseases pose a constant and considerable threat to health systems worldwide. Their emergence, spread, and rising incidences are closely connected to the growing populations and cases of migration across the world that are often associated with inadequate hygiene standards, in addition to the economic exploitation of ecosystems that leads to spillovers, and climate changes that enable vectors to conquer new habitats, immunologically harming those that live there. Rising infection numbers, which can lead to global pandemics, have both health-related and economic consequences all over the world. Thus, the development of efficient and well-tolerated drugs for the treatment of infectious tropical diseases caused by viruses, bacteria, or fungi, as well as by protozoal and worm parasites, is one of the main health care challenges of this century. The identification of new drug candidates with improved activity, selectivity, and ability to avoid or overcome drug-resistance mechanisms is mandatory in order to save lives and to prevent global crises in the future. Since many anti-infectives for neglected tropical diseases are either toxic (arsenics and antimonials) or expensive (liposomal amphotericin B), drug repurposing, as well as the development of cost-effective new compounds obtained from simple syntheses and multi-component reactions using inexpensive starting materials, appear to be especially auspicious. In addition, the identification and optimisation of anti-infectives by computer-aided drug design offer new opportunities. This Special Issue presents the current efforts regarding the design and development of drug candidates for the treatment of infectious tropical diseases. Original research articles, review articles, perspectives, and short communications including (but not restricted to) the described research fields are welcome. Dr. Bernhard Biersack
Dr. Bernhard Biersack
Guest Editor
Manuscript Submission Information
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Keywords
- • infectious diseases
- • tropical medicine
- • antiparasitic drugs
- • antibiotics
- • antiviral drugs
- • antifungal drugs
- • drug design
- • neglected tropical diseases
- • drug resistance
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