Molecular and Cellular Mechanisms in Cardiomyopathy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 April 2025 | Viewed by 572
Special Issue Editors
Interests: cardiovascular calcium handling in health and disease; in vivo models of cardiac hypertrophy and cardiotoxicity; cardiac fibroblasts; cardiomyocytes; vascular endothelial and smooth muscle cells in health and disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to invite contributions to this special issue on Molecular and Cellular Mechanism in Cardiomyopathy. The International Journal of Molecular Sciences is seeking the submission of original articles and review articles covering the scope of altered calcium regulation in cardiovascular disease and potential novel research applications along with therapeutic intervention.
Coordinated regulation of intracellular calcium levels is crucial for healthy cardiovascular function. This is particularly important in cardiac cells given the coupling of calcium cycling to ATP consumption during excitation-contraction coupling. There are a large variety of proteins (exchangers, channels and pumps) that contribute to the tight regulation of calcium transport throughout the cells of the heart. All of these proteins are modulated by a variety of molecular pathways that enable rapid functional changes in response to extracellular chemical or mechanical signals. Under pathological conditions where either acute or chronic cardiovascular stressors are present, there are temporary or sustained alterations in cardiac calcium regulation that can ultimately lead to cardiac hypertrophy, arrhythmias, heart failure and cardiomyopathies. These pathologies result from alterations in molecular signaling that contribute to the dysregulation of calcium handling within the cardiac cell. This special issue will focus on recent advances in our understanding of the defects in cardiac calcium handling which occur during cardiovascular disease. Specific attention will be given to the molecular mechanisms that are responsible for defective cardiovascular function and importantly, possible novel therapeutic interventions that can target these mechanisms and reduce or reverse the pathological phenotype.
We are seeking submissions that may include but are not exclusive to the following topics:
- Calcium handling in contractile and non-contractile cells of the heart in cardiomyopathy.
- Alterations in kinase expression, activity and localisation.
- Role of phosphodiesterases in cardiomyopathy.
- Alterations in calcium handling proteins in HFpEF versus HFrEF.
- Novel imaging approaches to assess molecular signaling in cardiomyopathy.
- Sex differences in calcium handling in cardiomyopathy.
- Drug therapies to reverse hypertrophy induced alterations in calcium signaling.
- Arrhythmias as well as class IV antiarrhythmics and calcium channel blockers.
We look forward to receiving your contributions.
Dr. Susan Currie
Dr. Niall MacQuaide
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- E-C coupling
- cardiac myocyte
- cardiac fibroblast
- ryanodine receptor
- SERCA2a
- CaMKII
- phosphodiesterase
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