Updates on Nanophotosensitizers
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 105
Special Issue Editor
Interests: cancer; reactive oxygen species; nanomedicine; anticancer agents; drug-delivery system; ROS-sensitive nanomaterials; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Photodynamic therapy (PDT) has been extensively investigated for the treatment of various diseases, such as cancers, infectious disease, and various abnormal disorders. Especially, photosensitizers in the absence of light have no toxicity against normal cells/tissues, and then PDT is a safe candidate for treatment of the cancer patients. Photosensitizers, which are accumulated in the tumor tissues, excessively generate reactive oxygen species (ROS) in the field of light irradiation with the appropriate wavelength of light. Then, oxidative stress occurs in this field and kills the cancer cells. However, some drawbacks of traditional photosensitizers are problematic in clinic applications, such as a lack of tumor specificity, spreading throughout the whole body, and phototoxicity (which is required to block sun light). Nanomedicines are normally characterized as nano-scale vehicles for the delivery of bioactive agents into disease cells/tissues of specific organs. Various nano-scaled vehicles, such as nanoparticles, polymeric micelles, liposomes, polymer conjugates, and carbon-based nanomaterials, can be used for the delivery of bioactive agents against specific cells or tissues. Furthermore, nanomedicine can be designed to be respond to the specific conditions of disease cells or tissues. For example, reactive oxygen species (ROS) and acidic pH-sensitive nanomedicines can be used for the targeting of cancer since oxidative stress and acidity in cancer cells is increased. Hyaluronic acid-decorated nanoparticles can also be used to target cancer cells because CD44 receptor expression in malignant cells is known to be increased.
Dr. Young-Il Jeong
Guest Editor
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Keywords
- photodynamic therapy
- oxidative stress
- reactive oxygen species
- stimuli-sensitive drug delivery
- nanomedicine
- nanophotosensitizer
- polymer
- drug targeting
- nano-vaccine
- theranosys
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