Recent Advances of HDL: Inflammation and Longevity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 407
Special Issue Editor
Interests: high-density lipoprotein (HDL); apoA-I; atherosclerosis; Alzheimer’s disease and dementia; hypertension
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hyperinflammation is intricately associated with the cytokine cascade of coronavirus disease-19 (COVID-19), resulting in acute death and chronic pain in individuals suffering from autoimmune diseases, rheumatoid arthritis (RA), psoriasis, and sepsis. The production of dysfunctional high-density lipoproteins (HDLs) can aggravate the inflammatory response, even though native HDL exerts antioxidant and anti-inflammatory activity. Indeed, native HDLs kill SARS-CoV2 via adequate paraoxonase activity.
Aging is a chronic process that involves several physical and biochemical modifications that affect HDL structure and function; this includes nonenzymatic glycation, which produces advanced glycated end products (AGEs). Aging is accompanied by an increase in circulating proinflammatory cytokines and acute-phase reactants such as interleukin-6, Serum Amyloid A and C-reactive protein. It has been established that when aging occurs, there is a decline in serum antioxidant activity, a cleavage of apoA-I, an increase in CETP activity, a reduction in the HDL particle size, an increase in SAA and apoC-III content in lipoproteins, and a pro-inflammatory change in the serum lipid profile.
HDLs possess many beneficial qualities and functionalities that prevent infection, inflammation, and the incidence of aging-related diseases, such as autoimmune diseases, cardiovascular diseases, diabetes, and dementia.
This Special Issue welcomes contributions that focus on the correlations between HDL quality, inflammation, and longevity in various stages of health, and the application of HDL-associated apolipoproteins and enzymes as therapeutic tools.
Prof. Dr. Kyung-Hyun Cho
Guest Editor
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Keywords
- high-density lipoproteins (HDL)
- inflammation
- longevity
- aging
- apoA-I
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