Molecular Insight into Autoinflammatory Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 53
Special Issue Editors
Interests: innate immunity; TLR9-signaling; autophagy; inflammation and cancer; inflammatory bowel disease; colorectal cancer; mucosal regeneration; immunology; gastroenterology; internal medicine
Special Issues, Collections and Topics in MDPI journals
Interests: inflammation; cancer; autophagy; carcinogenesis; innate immunity; autoimmune diseases; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Autoinflammatory disease (AIF) and autoimmune disease are two classifications of disorders that involve the immune system erroneously attacking healthy cells. Despite the numerous similarities among these inflammatory illnesses, distinct characteristics render each one distinctive. At one end of the inflammatory spectrum are the uncommon monogenic autoimmune disorders. At the opposite end are the equally rare monogenic autoinflammatory disorders. This category includes all diseases with an autoimmune phenotype and autoinflammatory characteristics, as well as those with autoinflammatory pathologies that exhibit partially autoimmune traits. Innate immunity issues lead to autoinflammatory disorders, whereas autoimmune diseases stem from the dysregulated adaptive immunity. Diseases that encompass both forms of immunity include ankylosing spondylitis, psoriatic arthritis, Behcet’s disease, and Crohn’s disease, among others.
AIFs are induced by changes in the genes that govern and modulate innate immune cells. Monogenic conditions, like familial Mediterranean fever and TNF receptor-associated periodic syndrome, stem from a single identifiable genetic flaw. Consequently, they may be hereditary. Autoinflammatory disorders are exceedingly uncommon. In contrast to autoimmune diseases, most AIFs manifest during childhood. The infrequency of these disorders, as well as their resemblance to other conditions, often result in delayed diagnosis. Clinical findings, as well as the age of onset and family history, can aid in the diagnosis of these rare illnesses. In certain instances, testing for genetic mutations is employed to validate a diagnosis of AIF.
The goal of the Special Issue is to include papers in which the authors map the molecular background of rare monogenic AIFs and more common AIFs with autoimmune features, investigate their clinical correlation, and present their therapeutic potential. Review articles, including rare case reports, are also welcome to assist clinicians not only in the diagnosis of the disease, but also in its therapy.
Dr. Ferenc Sipos
Prof. Dr. Györgyi Műzes
Guest Editors
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Keywords
- autoinflammation
- autoimmunity
- genetics
- epigenetics
- molecular pathogenesis
- therapy
- diagnosis
- rare cases
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