Molecular Mechanisms and Therapies of Hematological Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 December 2024 | Viewed by 327
Special Issue Editors
Interests: leukemia; diagnostic; MPN; NGS
Interests: acute myeloid leukemia; genomics; cell metabolism; targeted therapies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Hematological malignancies consist of different cancers including leukemias, lymphomas, multiple myeloma, myeloproliferative neoplasms, and myelodysplastic syndromes. Recent advances in sequencing technologies have better defined the genomic landscape of hematological diseases and partially explained the molecular mechanisms underlying the carcinogenesis processes. This led to the development of different target therapies such as IDH inhibitors or BCL2 inhibitors that can be used beyond the standard chemotherapy to target and resolve the complexity of hematological disease and improve patient outcomes. Recently, the pathogenic roles of KMT2A rearrangements have been elucidated and patients characterized by this structural alteration can take advantage from Menin inhibitor use. Despite this, leukemic stem cells possess different relapse/refractory mechanisms, for example, multi-drug resistance, responsible for the relapse of disease.
This Special Issue aims to explain new insights into genetic and epigenetic alterations, cancer metabolism, target therapies, therapy response, drug resistance and relapse of the disease. Both original research articles, including in vitro studies, and reviews articles are strongly invited for submission.
Dr. Maria Teresa Bochicchio
Dr. Giorgia Simonetti
Guest Editors
Manuscript Submission Information
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Keywords
- genetic alterations
- next-generation sequencing
- molecular biomarkers
- target therapy
- drug resistance
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