Renin-Angiotensin System in Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 191
Special Issue Editor
Interests: renal physiology; diabetic kidney disease; acute kidney injury; chronic kidney disease; proteinuria; hypertension; renal and renovascular hypertension; renal renin angiotensin system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Renin-angiotensin-aldosterone systems (RAAS) play critical roles in the regulation of blood pressure (BP), body fluid homeostasis, and cardiovascular function. Various tissues, including the heart and kidneys, possess individual locally regulated RAASs. Overactivity of the cardiac RAAS is associated with cardiac diseases, including cardiac hypertrophy due to volume and/or pressure overload, heart failure, coronary artery disease with myocardial infarction, and hypertension. The overactivity of the renal RAAS is associated with various kidney diseases such as nephropathies and renal artery stenosis. RAAS blockade with angiotensin-converting enzyme inhibitors (ACEIs) and/or angiotensin receptor AT(1) blockers (ARBs) is very useful for the treatment of arterial hypertension, chronic heart failure (CHF), chronic kidney disease (CKD), atherosclerosis, and diabetes. Then, attention has been paid to basic studies about new insights into molecular RAAS mechanisms in vitro and in vivo and clinical studies about RAAS blockers.
Recently, ACE2 is considered as a SARS-CoV-2 receptor and involved in the pathogenesis of coronavirus disease 2019 (COVID-19). ACE2 has important functions in the renin–angiotensin system (RAS): blood pressure maintenance and electrolyte homeostasis. Several reports found increases in ACE2 expression in the lung associated with numerous chronic comorbidities and as a function of increasing age, consistent with the risk for severe COVID-19. The influence of the RAAS on the progression of COVID-19 has been a topic of debate, and the full extent of RAAS involvement in the long-term consequences of COVID-19, such as long COVID and the cardiovascular thrombotic effects post-COVID, along with those following vaccination, remains not entirely resolved. The role of the RAAS in procoagulant processes during COVID-19 is of particular importance.
The purpose of this Special Issue is to present the current efforts in the involvement of the RAAS in the molecular mechanisms underpinning hypertension, CHD, and CKD, as well as procoagulant processes throughout COVID-19, from the viewpoint of pathogenesis of organ complications as well as clinical outcomes. Original research articles, review articles, and short communications within (but not limited to) the research areas described above are welcome.
Dr. Keiko Hosohata
Guest Editor
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Keywords
- coronavirus disease 2019 (COVID-19)
- SARS-CoV-2
- RAAS
- spike protein
- angiotensin
- ACE2
- clinical study
- basic experiments
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