Advances in Alpha-1 Antitrypsin Deficiency
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 52
Special Issue Editor
Interests: alpha-1 antitrypsin deficiency-associated liver disease; metabolic dysfunction-associated liver disease; pathogenesis; ER stress in liver pathophysiology; liver fibrogenesis; innate immunity; protein misfolding and the immune response; animal models for liver fibrogenesis
Special Issue Information
Dear Colleagues,
This Special Issue aims to provide an overview of alpha-1 antitrypsin deficiency, a genetic disorder characterized by liver disease, caused by misfolding and hepatic accumulation of mutant alpha-1 antitrypsin. This results in reduced levels of circulating alpha-1 antitrypsin, which plays a crucial role in protecting the lungs from protease-mediated damage. With contributions from leading researchers, this Special Issue explores the latest findings in the pathophysiology, genetic underpinnings, and clinical manifestations of alpha-1 antitrypsin deficiency.
Key topics include advances in diagnostic techniques, such as genetic screening and biomarkers, as well as the role of alpha-1 antitrypsin in inflammatory processes and organ protection. The Special Issue issue also addresses current therapeutic strategies, including enzyme replacement therapy and emerging treatments.
By collating cutting-edge research and expert insights, this Special Issue aims to foster a deeper understanding of AATD, ultimately guiding improved clinical practices and outcomes for those affected by alpha-1 antitrypsin deficiency.
Dr. Nazli Khodayari
Guest Editor
Manuscript Submission Information
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Keywords
- alpha-1 antitrypsin
- neutrophil elastase
- liver disease
- liver fibrosis
- lung disease
- inflammation
- emphysema
- diagnosis
- treatment strategies
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