Nrf1/2/3 and Other Antioxidant Transcription Factors in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 20
Special Issue Editor
Interests: molecular biology; biochemistry; biomaterials
Special Issue Information
Dear Colleagues,
Oxidative stress, a condition caused by the accumulation of reactive oxygen species, contributes to the onset and progression of various diseases by damaging cellular components such as lipids, proteins, and DNA. By contributing to inflammation, immune dysfunction, and tissue damage, oxidative stress plays a central role in several neurological and metabolic disorders (such as Parkinson’s, Alzheimer’s, Cardiovascular diseases, and diabetes) and in cancer. NRF1, NRF2, and NRF3 are cap'n'collar transcriptional factors that bind antioxidant-response elements in promoter regions of genes involved in antioxidant defence mechanisms. Oxidative stress can trigger other transcription factors like NF-kB, p53, or HIF-1. Managing oxidative stress is important to ensure a good immune response to pathogens and to maintain overall cellular health.
The aim of this Special Issue, entitled “Nrf1/2/3 and Other Antioxidant Transcription Factors in Health and Disease”, will be to provide a platform for publishing research on the role of transcriptional factors and their activation mechanisms in cellular response to oxidative stress in pathological or physiological conditions.
Understanding the molecular mechanisms involved in transcriptional factors is essential for developing new strategies to maintain cellular redox balance and mitigate oxidative damage. In this Special Issue, original research articles, short communications, and reviews are welcome.
Dr. Eleonora Stanca
Guest Editor
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Keywords
- transcription factor
- oxidative stress
- NRF1/2
- NRF3
- NFkB
- P53
- antioxidant-response elements
- neurologial diseases
- metabolic diseases
- cancer
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