The Role of Fibrinolytic Factors in Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 17
Special Issue Editor
Interests: antiplasmin; fibrinolysis; fibrosis; matrix metalloproteinases; plasmin inhibition
Special Issue Information
Dear Colleagues,
The fibrinolytic system is responsible for dissolving fibrin and maintaining vascular homeostasis through the action of plasmin. Plasmin is produced when the precursor plasminogen is activated by urokinase plasminogen activator (uPA)/uPA receptor (uPAR) or tissue-type plasminogen activator (tPA), and these plasminogen activators (PAs) are inhibited by plasminogen activator inhibitor 1 (PAI-1). Plasmin activity is further inhibited by α2-antiplasmin (α2AP). Recently, many studies have demonstrated that these fibrinolytic factors may have functions beyond thrombus dissolution and could contribute to the onset of various diseases. This Special Issue explores the roles of fibrinolytic factors in the pathogenesis of different diseases.
Dr. Yosuke Kanno
Guest Editor
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Keywords
- fibrinolysis
- plasminogen
- plasmin
- α2-antiplasmin
- uPA
- uPAR
- tPA
- PAI-1
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