Epigenetic Mechanisms in Cancer Biology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 179
Special Issue Editor
Interests: immunotherapy; genetics; personalized medicine; cancer epidemiology; molecular epidemiology; translational research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is now widely recognized that epigenetic dysregulation is a hallmark of cancer development and progression. Different epigenetic mechanisms, including DNA methylation, histone modifications, and RNA-mediated epigenetic regulation, among others, have been linked to a wide variety of cancer types, including but not limited to breast, prostate, lung, and colon cancer. Because epigenetic alterations are so ubiquitous in cancer, it has been postulated that epigenetic biomarkers can be useful for cancer screening and monitoring of treatment efficacy. Beyond that, epigenetic changes may prove to be useful targets for novel treatment strategies. However, important research gaps remain. The epigenome acts as the interface between the environment and the genome, yet the specific epigenetic changes elicited from environmental carcinogens, such as PFAS, are still being elucidated. Similarly, additional research is needed to better understand how the timing of environmental exposures impacts epigenetic changes, which likely varies across the life course. For that matter, a better understanding of the impact of aging on epigenetic changes is still needed, especially as cancer is a disease associated with increased age. The complex relationship between somatic DNA alterations and epigenetic changes is still not well understood, neither are the relationships between the impact of the tumor microenvironment and epigenetic changes, and vice versa. The synergistic or antagonistic effect of multiple epigenetic mechanisms on cancer development also warrants research. Studies that investigate these specific aspects of the mechanistic relationship between epigenetic alterations and cancer are warmly solicited for this Special Issue.
Dr. Stephanie J. Tuminello
Guest Editor
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Keywords
- epigenetics
- DNA methylation
- histones
- cancer
- cancer development
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