Molecular Linkages between Obesity, Diabetes and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 288
Special Issue Editor
Interests: cells signaling pathways; persistent pollutants; obesity
Special Issue Information
Dear Colleagues,
It is well known that the prevalence of obesity is progressively increasing in Western populations, doubling in the last three decades, and is considered the pandemic of the modern era. Obesity is a condition characterised by excess body fat and is a major risk factor for several chronic diseases, including type 2 diabetes and several types of cancer.
Obesity contributes to the development of type 2 diabetes by causing insulin resistance. Both obesity and diabetes are associated with an increased risk of developing certain types of cancer. Obesity may promote cancer through chronic inflammation, increased levels of insulin and growth factors and altered sex hormones. Diabetes may also contribute to cancer risk through elevated glucose and insulin levels, which can have mitogenic and anti-apoptotic effects on cells.
This Special Issue will accept articles that molecularly explore this interconnection through a series of complex biological mechanisms including chronic inflammation, insulin resistance and alterations in cell signalling, as well as the important toxicological role of adipose tissue with respect to lipophilic xenobiotic molecules.
Prof. Dr. Pilar F. Valerón
Guest Editor
Manuscript Submission Information
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Keywords
- obesity
- GLUT4
- PPARg
- lipid transporters (CD36 and AQP7)
- cancer progression
- metastasis
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