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Corneal Diseases and Corneal Transplantation: Current Updates and Perspectives
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Corneal Diseases and Corneal Transplantation: Current Updates and Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 784

Special Issue Editors

Dr. Itay Lavy

E-Mail Website
Guest Editor
Department of Ophthalmology, Faculty of Medicine, Hadassah-Hebrew University Medical Center, Hebrew University of Jerusalem, Jerusalem 91120, Israel
Interests: ophthalmology; myopia; corneal diseases; eye anterior segment; cataract; cornea
Dr. Nir Erdinest

E-Mail Website
Guest Editor
Department of Ophthalmology, Faculty of Medicine, Hadassah-Hebrew University Medical Center, Hebrew University of Jerusalem, Jerusalem 91120, Israel
Interests: cornea; corneal topography; myopia; keratoconus; contact lenses
Special Issues, Collections and Topics in MDPI journals
Dr. Michael Mimouni

E-Mail Website
Guest Editor
Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel
Interests: cornea; refractive surgery; cataract; anterior eye segment

Special Issue Information

Dear Colleagues,

As Guest Editors of the forthcoming Special Issue on corneal diseases and corneal transplantation, we warmly invite scholars, clinicians, and researchers to contribute original manuscripts that will enrich our collective understanding of these critical areas of ophthalmology. Corneal diseases can significantly impair vision, causing discomfort and leading to blindness if untreated. Corneal transplantation remains a pivotal intervention, offering hope to those with severe corneal damage.

This Special Issue aims to compile a comprehensive collection of peer reviewed articles exploring various topics related to corneal diseases and transplantation. We invite original articles or reviews focusing on, but not limited to, the following potential topics: prevalence and epidemiology of corneal diseases, advancements in diagnostic technologies and imaging techniques, and corneal transplantation outcomes and techniques.

We are particularly interested in manuscripts addressing the latest research on corneal endothelial, novel approaches to improve graft survival, the impact of donor and recipient factors on transplantation outcomes, and the application of artificial intelligence in corneal disease diagnosis and management. Additionally, insights into patient quality of life post-transplantation and strategies for addressing challenges in global access to corneal transplantation are highly welcome.

We are honored to invite contributors to submit their studies, helping to advance the field and improve patient care.

Dr. Itay Lavy
Dr. Nir Erdinest
Dr. Michael Mimouni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • corneal diseases
  • corneal transplantation
  • imaging techniques
  • pharmacological in-terventions
  • surgical interventions
  • tissue engineering

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

14 pages, 5383 KiB  
Article
Classification of Histologically Proven Inflammation in Clinically Inactive Corneal Scars: Implications for Graft Outcomes After Penetrating Keratoplasty
by Max Schliffka, Helena Siegel, Claudia Auw-Haedrich, Christian van Oterendorp, Daniel Boehringer and Thomas Reinhard
J. Clin. Med. 2025, 14(2), 461; https://doi.org/10.3390/jcm14020461 - 13 Jan 2025
Viewed by 411
Abstract
Background/Objectives: Clinically inactive corneal scars have repeatedly been shown to exhibit histological inflammation. This study aimed to evaluate the degree of histological inflammation in clinically inactive corneal scars of different origins and its correlation with graft rejection and failure following penetrating keratoplasty. [...] Read more.
Background/Objectives: Clinically inactive corneal scars have repeatedly been shown to exhibit histological inflammation. This study aimed to evaluate the degree of histological inflammation in clinically inactive corneal scars of different origins and its correlation with graft rejection and failure following penetrating keratoplasty. Methods: The study included 205 primary corneal explants with clinically inactive central scars resulting from herpes simplex virus keratitis (HSV, n = 55), keratoconus (n = 39), mechanical trauma (n = 27), scrophulosa (n = 22) or other/unknown causes (n = 62). Central histological sections were categorized by the degree of inflammation, and an overall inflammation score (IS) was calculated. Results: HSV-associated scars exhibited a trend towards more graft rejection with higher IS (p = 0.074). Keratoconus-associated scars showed no IS-dependent differences in graft rejection or failure. The rejection rate in this group was 13/39. Scars resulting from mechanical trauma, such as perforating injuries, demonstrated a trend towards higher graft rejection (p = 0.15) and failure rates (p = 0.089) with increasing IS. The rejection rate in this group was 11/27. Scrophulosa-associated scars had significantly higher graft rejection rates (p = 0.041) at a lower cut-off of 0.06 compared to the cut-off of 0.36 for the other groups. Scars of other or unknown causes showed no IS-dependent differences in graft rejection or failure. Conclusions: Histological inflammation in HSV scars and scars resulting from mechanical trauma appeared to contribute to graft rejection. Despite low IS, the rejection rate in keratoconus scars and scars following mechanical trauma was unexpectedly high, indicating the presence of other influencing factors. While some correlations did not reach statistical significance due to small sample sizes in the subgroups, the observed trends should be considered clinically relevant. The study may have been “underpowered”, as histopathologically inflamed specimens with clinically inactive corneal scars are relatively rare. Full article
(This article belongs to the Special Issue Corneal Diseases and Corneal Transplantation: Current Updates and Perspectives)
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