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Adverse Pregnancy Outcomes: Current Status, Challenges and Future Directions
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Adverse Pregnancy Outcomes: Current Status, Challenges and Future Directions

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 10 March 2025 | Viewed by 1960

Special Issue Editors

Dr. Demetra Socolov

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Guest Editor
Department of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: maternal–fetal medicine; in utero fetal surgery; prenatal diagnosis; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Iuliana Ceausu

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Guest Editor
Department of Obstetrics and Gynaecology, “Carol Davila” University of Medicine and Pharmacy, "Dr I. Cantacuzno" Hospital, 020021 Bucharest, Romania
Interests: Biomarkers in obstetrics and gynaecology; gestational diabetes; maternal obesity; autoimmune diseases and pregnancy; preeclampsia; fetal medicine
Dr. Elena Bernad

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Interests: gynecology; obstetrics; gynecological oncology; endocrinology and reproductive medicine; ethics; medical education; research design; epidemiology and statistics; computer applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Adverse pregnancy outcomes pose a substantial challenge for obstetricians, with long-term consequences on maternal and neonatal health, including neurological injuries as well as cardiovascular and metabolic disorders. Current screening strategies and prophylactic measures have substantially influenced the incidence of these adverse outcomes. However, recent advancements in detection rates of obstetrical disorders using various biochemical, sonographic, genomic, and proteomic markers, as well as advanced screening algorithms powered by artificial intelligence, need to be highlighted.

This Special Issue, entitled “Adverse Pregnancy Outcomes: Current Status, Challenges, and Future Directions,” will focus on recent advancements in the screening, prediction, and diagnosis of maternal and neonatal outcomes in the context of preeclampsia, intrauterine growth restriction, preterm birth, gestational diabetes, and intraamniotic infections. Additionally, it will support the peer review of manuscripts that describe the prenatal and intrapartum management of high-risk pregnancies and their outcomes.

We welcome high-quality and informative original studies (clinical and experimental), meta-analyses, reviews, clinical cases, and expert opinions. We look forward to receiving your contributions!

Dr. Demetra Socolov
Prof. Dr. Iuliana Ceausu
Dr. Elena Bernad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • great obstetrical syndromes
  • adverse pregnancy outcomes
  • screening
  • prediction
  • prophylaxis
  • diagnosis
  • long-term follow-up
  • perinatal management
  • intrapartum management

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Published Papers (2 papers)

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Research

11 pages, 252 KiB  
Article
Multidrug-Resistant Urinary Tract Infections in Pregnant Patients and Their Association with Adverse Pregnancy Outcomes—A Retrospective Study
by Gabriel-Ioan Anton, Liliana Gheorghe, Viorel-Dragos Radu, Ioana-Sadiye Scripcariu, Ingrid-Andrada Vasilache, Alexandru Carauleanu, Iustina-Solomon Condriuc, Razvan Socolov, Pavel Onofrei, Andreea-Ioana Pruteanu, Ramona-Gabriela Ursu, Tudor Gisca and Demetra Socolov
J. Clin. Med. 2024, 13(22), 6664; https://doi.org/10.3390/jcm13226664 - 6 Nov 2024
Viewed by 485
Abstract
Background/Objectives: Multidrug-resistant urinary tract infections (MDR UTIs) constitute an important public health problem, especially in pregnant patients. The aim of this retrospective study was to characterize the bacterial spectrum and the profile of microbial resistance in cases of UTIs occurring in pregnant [...] Read more.
Background/Objectives: Multidrug-resistant urinary tract infections (MDR UTIs) constitute an important public health problem, especially in pregnant patients. The aim of this retrospective study was to characterize the bacterial spectrum and the profile of microbial resistance in cases of UTIs occurring in pregnant women, as well as their impact on obstetrical and neonatal outcomes. Methods: A total of 371 pregnant patients with UTIs were included in the analysis and were segregated into the following groups based on the type of bacterial resistance to antibiotics: MDR UTIs (70 patients, group 1), UTIs resistant to one class of antibiotics (108 patients, group 2), UTIs resistant to two classes of antibiotics (102 patients, group 3), and sensitive UTIs (91 patients, group 4). We used descriptive statistics for characterizing and comparing the microbial spectrum and the clinical characteristics of the patients. A multinomial logistic regression model for evaluating the relationship between the type of urinary tract infection and adverse obstetric or neonatal outcomes was employed. Results: In the case of MDR UTIs, the bacterial spectrum mainly included Escherichia coli, Enterococcus faecalis, and Klebsiella species. We found almost universal resistance to ampicillin. Our data confirmed an increased risk of preterm birth, premature rupture of membranes, neonatal respiratory distress syndrome, and neonatal intensive care unit admission for patients with MDR infections. Conclusions: The increased incidence of pathogens resistant to commonly used antibiotic classes in pregnancy suggests the need for the development of local and national protocols that adapt therapeutic and prophylactic regimens to clinical realities. Full article
(This article belongs to the Special Issue Adverse Pregnancy Outcomes: Current Status, Challenges and Future Directions)
12 pages, 423 KiB  
Article
Maternal and Perinatal Outcomes in Pregnant Women with Heart Disease: A Case—Control Study
by Irene Aracil Moreno, Raquel Prieto-Arévalo, Virginia Ortega-Abad, Virginia Martín-Manzano, Laura Pérez-Burrel, Andrea Fraile-López, Carolina Devesa-Cordero, Fátima Yllana-Pérez, Miguel A. Ortega and Juan A. De León-Luis
J. Clin. Med. 2024, 13(17), 5084; https://doi.org/10.3390/jcm13175084 - 27 Aug 2024
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Abstract
Objective: We analyzed the obstetric and cardiac characteristics and results of pregnant women with heart disease (HD) and compared their results with those of healthy controls. Methods: In this retrospective single-center case–control study, women with HD attended between 2010 and 2018 [...] Read more.
Objective: We analyzed the obstetric and cardiac characteristics and results of pregnant women with heart disease (HD) and compared their results with those of healthy controls. Methods: In this retrospective single-center case–control study, women with HD attended between 2010 and 2018 were matched at a 1:2 ratio (according to date of delivery, parity, and singleton or twin pregnancy) with controls without heart disease treated in the same referral center. Results: We identified 141 pregnant women with HD, of whom 132 reached 22 weeks of gestation and were paired with 264 healthy controls, for a total of 396 participants and 408 newborns. Most common HDs were congenital HD (53 women), arrhythmia (46), valvular HD (35), and cardiomyopathy (16), having women with more than one coexisting HD. During pregnancy or the puerperium, 19.9% of mothers experienced a major adverse cardiac event (MACE), with 5% requiring intensive care unit (ICU) admission. The rates of cesarean section were 37.1% in the case group and 18.2% in the control group, with an odds ratio (OR) of 2.66 (95% CI = 1.66–4.26, p < 0.001). We also found a higher use of general anesthesia, with an OR of 10.73 (95% CI = 2.32–49.75, p = 0.002); more prolonged hospitalizations, with an OR of 2.91 (95% CI 1.02–8.35, p = 0.023); and a higher incidence of low neonatal weight, with an OR of 1.96 (95% CI 1.09–3.52, p = 0.012). There were no differences between groups in terms of gestational age at delivery; however, we observed greater prematurity in women with HD, without reaching statistical significance. The rate of congenital heart disease among the newborns of mothers with HD was 13.2%. Conclusions: HD increases maternal morbidity during pregnancy and it is associated with higher rates of cesarean section and low birth weight. Full article
(This article belongs to the Special Issue Adverse Pregnancy Outcomes: Current Status, Challenges and Future Directions)
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