Chronic Complications of Type 2 Diabetes: Prevalence, Prevention, and Management

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 25 January 2025 | Viewed by 438

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Director of Diabetes Centre, Lefkos Stavros Hospital, 115 28 Athens, Greece
Interests: chronic complications of diabetes; prevention of diabetes
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Dear Colleagues,

The prevalence of type 2 diabetes is increasing rapidly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. Chronic complications of type 2 diabetes are due to myriad disorders and numerous metabolic pathways that are responsible for most of the morbidity and mortality associated with the disease. These are, in general, divided into micro- and macrovascular complications. Microvascular complications in diabetes result from the impairment of small blood arteries, leading to a large increase in morbidity. Retinopathy, nephropathy, and neuropathy are prevalent microvascular consequences. The development of microvascular problems in diabetes is closely associated with the combined impact of long-term high blood sugar levels, abnormal lipid levels, and high blood pressure. The major forms of macrovascular disease are coronary heart disease, stroke, and peripheral vascular disease, which share both an atherosclerotic background and several common risk factors. The relationship between diabetes and cardiovascular illness is complex, encompassing dyslipidemia, hypertension, and a proinflammatory state associated with diabetes cardiovascular events, which remains the major cause of death for those with diabetes.

We call on clinicians, researchers, and healthcare professionals to contribute their expertise and findings to this Special Issue. By consolidating knowledge and fostering clinical innovation, we aim to improve the prevention, diagnosis, and treatment of chronic complications in type 2 diabetes, ultimately enhancing patient outcomes and quality of life.

Dr. Ilias Migdalis
Guest Editor

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Keywords

  • pathogenesis of diabetic complications
  • epidemiology of diabetic complications
  • diabetic retinopathy
  • diabetic chronic kidney disease
  • diabetes neuropathies
  • coronary heart disease
  • peripheral vascular disease
  • hypertension and dyslipidemia in diabetes

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Published Papers (1 paper)

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Research

15 pages, 1808 KiB  
Article
Risk Factors for Cataracts in Patients with Diabetes Mellitus
by Adriana Ivanescu, Simona Popescu, Laura Gaita, Oana Albai, Adina Braha and Romulus Timar
J. Clin. Med. 2024, 13(23), 7005; https://doi.org/10.3390/jcm13237005 - 21 Nov 2024
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Abstract
Background: Diabetes mellitus (DM) is one of the most impactful health problems worldwide. It affects ocular health in multiple ways and is one of the leading causes of vision loss. Our study aimed to evaluate the most important systemic risk factors related to [...] Read more.
Background: Diabetes mellitus (DM) is one of the most impactful health problems worldwide. It affects ocular health in multiple ways and is one of the leading causes of vision loss. Our study aimed to evaluate the most important systemic risk factors related to the occurrence of cataracts in patients with DM. Method: This study evaluated a final number of 319 participants who were previously diagnosed with DM. For all patients, we retrieved data regarding DM status, metabolic control, demographic and anthropometric indices, and generally associated comorbidities from their medical charts. A comprehensive eye examination was performed on all patients. Results: The main studied risk factors were hypertension, cardiovascular disease (CVD), chronic kidney disease (CKD), diabetic polyneuropathy (DPN), dyslipidemia, and hepatic steatosis, which were present among the entire population. Hypertension (67.6%), DPN (53.3%), and dyslipidemia (46.6%) were highly prevalent in the cataract subgroup, and CKD (p < 0.001) and DPN (p = 0.019) were found to be predictive factors for the probability of cataract occurrence. Ophthalmologic evaluation was used to assess the presence of ocular complications, such as diabetic retinopathy (DR) and diabetic maculopathy. DR reached statistically significant values in the occurence of cataracts. Patients’ age and DM-related factors, such as disease duration (p < 0.001) and HbA1c values (p = 0.029), significantly increased the risk of cataracts. Smoking was self-reported by 24.8% of the patients, with a significant impact on the occurrence of cataracts (p = 0.04). Conclusions: Patients with DM who exhibit a longer disease duration and poor glycemic control in conjunction with systemic comorbidities present a higher risk of developing cataracts; consequently, a strict therapeutic approach regarding these risk factors is needed. Full article
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