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The Future of Vascular Medicine and Angiogenesis
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The Future of Vascular Medicine and Angiogenesis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383).

Deadline for manuscript submissions: closed (29 February 2016)

Special Issue Editor

Prof. Dr. Michael Simons

E-Mail Website
Guest Editor
Yale University School of Medicine, 300 George Street, 7th Floor, New Haven, CT 06519, USA
Interests: angiogenesis; vascular biology; arteriogenesis; VEGF; FGF; endothelial biology

Special Issue Information

Dear Colleagues,

The failure of arterial blood supply underlies a number of the most common cardiovascular illnesses, including myocardial infarction, stroke, coronary artery disease, and peripheral artery disease, among others. Furthermore, defective neovascularization is an important component of the pathobiology of such illnesses as diabetes, atherosclerosis, and hypertension. Despite much effort, attempts at therapeutic revascularization have not yet been successful. However, recent developments in the field promise to change that.

This Special Issue of the Journal of Clinical Medicine will cover the following important aspects of this field:

  • Molecular understanding of angiogenesis and arteriogenesis
  • Molecular basis of defective neovascularization in systemic diseases
  • Angiogenic paradox in diabetes
  • Vascular complications in diabetes
  • Vascular defects in atherosclerosis and arteriosclerosis
  • Obesity, hypertension and defective neovascularization
  • New therapeutic developments
  • Drug delivery to the vasculature
Prof. Dr. Michael Simons
Guest Editor

Keywords

  • angiogenesis
  • arteriogenesis
  • therapeutic angiogenesis
  • VEGF
  • ischemia
  • anti-angiogenesis
  • CAD
  • PAD
  • collateral circulation

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Published Papers (2 papers)

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Review

2032 KiB  
Review
Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology
by Reza Golestani, Jae-Joon Jung and Mehran M. Sadeghi
J. Clin. Med. 2016, 5(6), 57; https://doi.org/10.3390/jcm5060057 - 6 Jun 2016
Cited by 16 | Viewed by 6047
Abstract
Angiogenesis and vascular remodeling are involved in a wide array of cardiovascular diseases, from myocardial ischemia and peripheral arterial disease, to atherosclerosis and aortic aneurysm. Molecular imaging techniques to detect and quantify key molecular and cellular players in angiogenesis and vascular remodeling (e.g., [...] Read more.
Angiogenesis and vascular remodeling are involved in a wide array of cardiovascular diseases, from myocardial ischemia and peripheral arterial disease, to atherosclerosis and aortic aneurysm. Molecular imaging techniques to detect and quantify key molecular and cellular players in angiogenesis and vascular remodeling (e.g., vascular endothelial growth factor and its receptors, αvβ3 integrin, and matrix metalloproteinases) can advance vascular biology research and serve as clinical tools for early diagnosis, risk stratification, and selection of patients who would benefit most from therapeutic interventions. To target these key mediators, a number of molecular imaging techniques have been developed and evaluated in animal models of angiogenesis and vascular remodeling. This review of the state of the art molecular imaging of angiogenesis and vascular (and valvular) remodeling, will focus mostly on nuclear imaging techniques (positron emission tomography and single photon emission tomography) that offer high potential for clinical translation. Full article
(This article belongs to the Special Issue The Future of Vascular Medicine and Angiogenesis)
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Review
Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine
by Sai-Wang Seto, Dennis Chang, Anita Jenkins, Alan Bensoussan and Hosen Kiat
J. Clin. Med. 2016, 5(6), 56; https://doi.org/10.3390/jcm5060056 - 6 Jun 2016
Cited by 95 | Viewed by 8428
Abstract
Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such as acidosis, glutamate excitotoxicity, calcium overload, cerebral inflammation and reactive [...] Read more.
Stroke is one of the major causes of death and adult disability worldwide. The underlying pathophysiology of stroke is highly complicated, consisting of impairments of multiple signalling pathways, and numerous pathological processes such as acidosis, glutamate excitotoxicity, calcium overload, cerebral inflammation and reactive oxygen species (ROS) generation. The current treatment for ischemic stroke is limited to thromolytics such as recombinant tissue plasminogen activator (tPA). tPA has a very narrow therapeutic window, making it suitable to only a minority of stroke patients. Hence, there is great urgency to develop new therapies that can protect brain tissue from ischemic damage. Recent studies have shown that new vessel formation after stroke not only replenishes blood flow to the ischemic area of the brain, but also promotes neurogenesis and improves neurological functions in both animal models and patients. Therefore, drugs that can promote angiogenesis after ischemic stroke can provide therapeutic benefits in stroke management. In this regard, Chinese herbal medicine (CHM) has a long history in treating stroke and the associated diseases. A number of studies have demonstrated the pro-angiogenic effects of various Chinese herbs and herbal formulations in both in vitro and in vivo settings. In this article, we present a comprehensive review of the current knowledge on angiogenesis in the context of ischemic stroke and discuss the potential use of CHM in stroke management through modulation of angiogenesis. Full article
(This article belongs to the Special Issue The Future of Vascular Medicine and Angiogenesis)
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