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Diabetic Foot Complications: Current Challenges and Future Prospects—3rd Edition
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Diabetic Foot Complications: Current Challenges and Future Prospects—3rd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: 15 April 2025 | Viewed by 2848

Special Issue Editors

Prof. Dr. Luigi Uccioli

E-Mail Website
Guest Editor
Diabetic Foot Unit, Department Systems Medicine, University of Rome Tor Vergata, Rome, Italy
Interests: diabetic foot; diabetic foot ulcers; diabetic foot infections; diabetic foot osteomyelitis; diabetic symmetric polyneuropathy; peripheral atherial disease; charcot foot
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. José Luis Lázaro-Martínez

E-Mail Website
Guest Editor
Diabetic Foot Unit, Universidad Complutense de Madrid, Madrid, Spain
Interests: diabetic foot; diabetic foot ulcers; diabetic foot infections; diabetic foot osteomyelitis; diabetic symmetric polyneuropathy; charcot foot
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This is the third edition of the Special Issue “Diabetic Foot Complications: Current Challenges and Future Prospects”.

The previous two editions were quite successful, with a large number of manuscripts about different topics in diabetic foot diseases, including meta-analyses, systematic revisions, and novel studies about promising techniques that could improve diabetic foot management and lower limb ailments (https://www.mdpi.com/journal/jcm/special_issues/Diabetic_Foot_Complications_2, https://www.mdpi.com/journal/jcm/special_issues/Diabetic_Foot).

Diabetic foot is a growing complication due to the global rise in Diabetes mellitus prevalence, affecting 9.1 to 26.1 million people annually worldwide and between approximately 19% and 34% of people with diabetes at least once in their life. Diabetic foot is sometimes associated with lower limb amputations and higher rates of mortality than some kinds of cancer, such as breast cancer or prostate cancer. In recent years, evidence has been focused on the management of the main complications that lead patients to limb loss, such as diabetic foot infections or peripheral vascular disease. The majority of studies investigate outcomes over the acute phase when a patient has a complicated diabetic foot ulcer. However, long-term studies, randomized control trials, and studies on prevention, both primary and secondary, are still few in the literature. On the other hand, the benefits of a multidisciplinary team on patient outcomes, health care system organization, and the competences of different specialties and health care professionals and what the impact is of different organizational and structural approaches are not yet very well studied in the literature. With this Special Issue, we hope to encourage submissions that discuss the current state of the art, address ongoing knowledge gaps, and focus on ongoing controversies related to diabetic foot complications.

Prof. Dr. Luigi Uccioli
Prof. Dr. José Luis Lázaro-Martínez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic foot ulcers
  • diabetic foot infections
  • charcot foot
  • peripheral vascular disease
  • prevention diabetic foot
  • lower limb amputation
  • diabetic foot mortality
  • biomechanics of diabetic foot

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Related Special Issue

Published Papers (2 papers)

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Research

12 pages, 1201 KiB  
Article
The Appropriateness of Footwear in Diabetic Patients Observed during a Podiatric Examination: A Prospective Observational Study
by Anisa Hazbiu, Ilaria Teobaldi, Mario Sepe, Giovanni Federici, Marco Meloni and Luigi Uccioli
J. Clin. Med. 2024, 13(8), 2402; https://doi.org/10.3390/jcm13082402 - 20 Apr 2024
Viewed by 1421
Abstract
Background: Adequate compliance with wearing therapeutic footwear (TF) to prevent diabetic foot ulcers is known to be low. The primary aim of this study was to identify population awareness about the ulceration and/or recurrence risk according to footwear choice. The secondary aim was [...] Read more.
Background: Adequate compliance with wearing therapeutic footwear (TF) to prevent diabetic foot ulcers is known to be low. The primary aim of this study was to identify population awareness about the ulceration and/or recurrence risk according to footwear choice. The secondary aim was to evaluate the compliance level in footwear choice based on a patient’s own risk. Methods: Forty podiatrists participated from 1 September 2017 to 31 August 2018, providing six-section forms which included personal data, risk classification, footwear characteristics and a knowledge questionnaire. Results: This study included 1507 patients. Those with active ulcers were excluded. A total of 43% of patients belonged to risk class 0, 19% to risk class 1, 19% to risk class 2 and 19% to risk class 3. A total of 58% had foot deformities. Conclusions: Nearly half of patients with a high risk of ulceration had knowledge of their own risk but the majority of them did not follow the recommendations. Only a small percentage (36%) of risk class 3 patients wore footwear suitable for their risk class. There was poor consideration of footwear choice among patients. We highlight critical issues in patient education and compliance with wearing footwear appropriate to their risk class. Full article
(This article belongs to the Special Issue Diabetic Foot Complications: Current Challenges and Future Prospects—3rd Edition)
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9 pages, 431 KiB  
Article
Diagnostic Performance of Atherogenic Index of Plasma for Predicting Diabetic Foot Osteomyelitis with Peripheral Artery Disease
by Sebastián Flores-Escobar, Mateo López-Moral, Marta García-Madrid, Francisco J. Álvaro-Afonso, Aroa Tardáguila-García and José Luis Lázaro-Martínez
J. Clin. Med. 2024, 13(7), 1934; https://doi.org/10.3390/jcm13071934 - 27 Mar 2024
Viewed by 1098
Abstract
Background: This study aims to assess the atherogenic index of plasma (AIP) diagnostic value in detecting diabetic foot osteomyelitis (DFO) among patients with diabetic foot ulcers (DFUs). Methods: A prospective cohort study was conducted on 80 patients with DFUs and suspected DFO between [...] Read more.
Background: This study aims to assess the atherogenic index of plasma (AIP) diagnostic value in detecting diabetic foot osteomyelitis (DFO) among patients with diabetic foot ulcers (DFUs). Methods: A prospective cohort study was conducted on 80 patients with DFUs and suspected DFO between January 2022 and December 2023. The primary outcome measures included the diagnosis of DFO, determined by positive microbiological analysis results from bone samples and its correlation with the AIP. Receiver operating characteristic (ROC) curves were utilized to select the optimal diagnostic cut-off points for AIP and post hoc analysis was performed to evaluate the difference in the AIP for diagnosing DFO in patients with and without peripheral arterial disease (PAD). Results: The diagnostic potential for DFO in PAD patients of AIP-1 (Log TC/HDL) showed an AUC of 0.914 (p < 0.001 [0.832–0.996]), leading to a sensitivity of 83% and a specificity of 85%. By contrast, AIP-2 (Log TG/HDL) demonstrated a slightly lower AUC of 0.841 (p < 0.001 [0.716–0.967]), leading to a sensitivity of 76% and a specificity of 74%. Conclusions: The AIP tool, with its ideal blend of sensitivity and specificity, aids in predicting DFO effectively. Therefore, clinicians should consider using AIP for patients suffering from PAD and associated DFO. Full article
(This article belongs to the Special Issue Diabetic Foot Complications: Current Challenges and Future Prospects—3rd Edition)
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