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JSOPB 2023–2024 Congress Special Issue—Update on Organ Preservation and Transplantation
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JSOPB 2023–2024 Congress Special Issue—Update on Organ Preservation and Transplantation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1081

Special Issue Editors

Prof. Dr. Issei Saitoh

E-Mail Website
Guest Editor
Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851-1, Hozumi, Mizuho, Gifu 501-0296, Japan
Interests: stem cells; cell therapy; pediatric dentistry
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Takashi Kenmochi

E-Mail Website
Guest Editor
Department of Organ Transplant Surgery, School of Medicine, Fujita Health University, Toyoake, Japan
Interests: pancreas transplantation; kidney transplantation; pancreatic islet transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a collection of selected papers from the 49th Japanese Society for Organ Preservation and Biology (JSOPB) (http://jognbio.umin.jp/). The Journal of Clinical Medicine (JCM) is providing an opportunity to publish selected data presented at the annual meeting.

The JSOPB was founded in 1974 with the aim of studying organ preservation and rapidly developed during the 1990s following the participation of researchers in various fields of medicine, pharmacology, engineering, veterinary medicine, and basic science. Currently, the JSOPB has more than 700 members and operates under the direction of its president, Prof. Mamoru Kusaka.

The most outstanding presentations made at the 49th annual meeting of the JSOPB—held on 20–21 October 2023, in Hokkaido, Japan, under the supervision of Prof. Naoto Matsuno (Asahikawa Medical University School of Medicine Medical Course Clinical Medicine Surgery, Asahikawa, Japan)—were selected and given the opportunity to be published in this Special Issue of JCM.

One of the vital objectives of the annual meeting of the JSOPB is to exchange new research outcomes and create new therapeutic concepts. Therefore, the aim of the present Special Issue is as follows:

  • Organ preservation and transplantation;
  • Organ/tissue engineering;
  • Stem cell therapy.

Prof. Dr. Issei Saitoh
Prof. Dr. Takashi Kenmochi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organ preservation
  • transplantation
  • pharmacology
  • engineering
  • stem cell therapy

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Related Special Issue

Published Papers (2 papers)

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Research

10 pages, 857 KiB  
Article
The Development of a Predictive Model for Postoperative Renal Function in Living Kidney-Transplant Donors
by Ryo Tanaka, Ayumu Taniguchi, Yoko Higa-Maegawa, Soichi Matsumura, Shota Fukae, Shigeaki Nakazawa, Yoichi Kakuta and Norio Nonomura
J. Clin. Med. 2024, 13(23), 7090; https://doi.org/10.3390/jcm13237090 - 23 Nov 2024
Viewed by 257
Abstract
Background/Objectives: The accurate prediction of postoperative renal function (post-RF) in living kidney donors is essential for optimizing donor safety and long-term health. After nephrectomy, renal function can be significantly altered, owing to the functional adaptation of the remaining kidney; however, the extent [...] Read more.
Background/Objectives: The accurate prediction of postoperative renal function (post-RF) in living kidney donors is essential for optimizing donor safety and long-term health. After nephrectomy, renal function can be significantly altered, owing to the functional adaptation of the remaining kidney; however, the extent of this has not been investigated. This study aimed to examine how various donor factors affect functional adaptation after nephrectomy, and to develop a new predictive model. Methods: In total, 310 patients who underwent donor nephrectomy were included. Preoperative split renal function (pre-SRF) of the remaining kidney was measured. Post-RF was measured 1 month after surgery. The functional adaptation rate was calculated from the difference between pre-SRF and post-RF. Multiple regression analysis was performed to develop a predictive formula for post-RF, incorporating donor age and pre-SRF. Results: The median age of the donors was 60 years, and 38.7% were men. The median pre-SRF was 36.4 mL/min/1.73 m2. The median functional adaptation rate was 26.8%, with donor age, pre-SRF, and a history of hyperuricemia (HUA) being significant predictors of the functional adaptation rate. The equation for post-RF was established as 0.94 × pre-SRF − 0.12 × age + 18.87 mL/min/1.73 m2. The estimated post-RF showed a high coefficient of determination (R2 = 0.76), with a mean bias of –0.01 mL/min/1.73 m2. Conclusions: Donor age, pre-SRF, and HUA are key predictors of renal functional adaptation after nephrectomy. The developed formula accurately estimates post-RF, supporting clinical decision-making and donor counseling for living kidney donations. Full article
(This article belongs to the Special Issue JSOPB 2023–2024 Congress Special Issue—Update on Organ Preservation and Transplantation)
14 pages, 6295 KiB  
Article
Scratch-Based Isolation of Primary Cells (SCIP): A Novel Method to Obtain a Large Number of Human Dental Pulp Cells Through One-Step Cultivation
by Yuki Kiyokawa, Masahiko Terajima, Masahiro Sato, Emi Inada, Yuria Hori, Ryo Bando, Yoko Iwase, Naoko Kubota, Tomoya Murakami, Hiroko Tsugane, Satoshi Watanabe, Takahiro Sonomura, Miho Terunuma, Takeyasu Maeda, Hirofumi Noguchi and Issei Saitoh
J. Clin. Med. 2024, 13(23), 7058; https://doi.org/10.3390/jcm13237058 - 22 Nov 2024
Viewed by 291
Abstract
Background: Dental pulp (DP) is a connective tissue composed of various cell types, including fibroblasts, neurons, adipocytes, endothelial cells, and odontoblasts. It contains a rich supply of pluripotent stem cells, making it an important resource for cell-based regenerative medicine. However, current stem cell [...] Read more.
Background: Dental pulp (DP) is a connective tissue composed of various cell types, including fibroblasts, neurons, adipocytes, endothelial cells, and odontoblasts. It contains a rich supply of pluripotent stem cells, making it an important resource for cell-based regenerative medicine. However, current stem cell collection methods rely heavily on the enzymatic digestion of dissected DP tissue to isolate and propagate primary cells, which often results in low recovery rates and reduced cell survival, particularly from deciduous teeth. Methods: We developed a novel and efficient method to obtain a sufficient number of cells through a one-step cultivation process of isolated DP. After the brief digestion of DP with proteolytic enzymes, it was scratched onto a culture dish and cultured in a suitable medium. By day 2, the cells began to spread radially from DP, and by day 10, they reached a semi-confluent state. Cells harvested through trypsinization consistently yielded over 1 million cells, and after re-cultivation, the cells could be propagated for more than ten passages. Results: The proliferative and differentiation capacities of the cells after the 10th passage were comparable to those from the first passage. The cells expressed alkaline phosphatase as an undifferentiation marker. Similarly, they also maintained the constitutive expression of stem cell-specific markers and differentiation-related markers, even after the 10th passage. Conclusions: This method, termed “scratch-based isolation of primary cells from human dental pulps (SCIP)”, enables the efficient isolation of a large number of DP cells with minimal equipment and operator variability, while preserving cell integrity. Its simplicity, high success rate, and adaptability for patients with genetic diseases make it a valuable tool for regenerative medicine research and clinical applications. Full article
(This article belongs to the Special Issue JSOPB 2023–2024 Congress Special Issue—Update on Organ Preservation and Transplantation)
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