Innervation of the Human Skin: From the Structure and Function to the Pathology
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 32228
Special Issue Editor
Interests: Neuroanatomy; Peripheral Nervous System; Somatosensitivity and Sensory pathways; Autonomic Nervous System; Mechanoreceptors and sensory corpuscles; Ion channels; Growth factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human skin is supplied by somatosensory and autonomic nerves. The former ending in the dermis forming different morphotypes of sensory corpuscles, and free nerve endings (dermal and epidermal), or contacting specialized epithelial cells, like Merkel cells. The sensory corpuscles and the Merkel cell-neurite complexes are involved in the detection of different forms of mechanosensation. Free nerve endings are particularly related to nociception. In recent years, the molecular mechanisms of the functioning of these sensory formations have been clarified, and recently it has been reported that not only the axons but also the glial cells that form them could participate in touch detection. As for the autonomic nerves, they are in relation to the efferent innervation of the glands and blood vessels of the skin, participating in processes such as sweating or control of vascular pressure. Both somatosensory nerve fibers and sensitive corpuscles, as well as autonomic fibers, are altered in some systemic metabolic diseases, neurodegenerative diseases, specific diseases of the nerves, as well as tumors as in the case of Merkel cells.
This Special Issue of Journal of Clinical Medicine aims to update all those aspects related to the skin nervous system.
Prof. Dr. José A. Vega
Guest Editor
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Keywords
- sensory nerves
- autonomic nerves
- sensory corpuscles
- Merkel cells
- pain
- itch
- tumors
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