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Basics, Epidemiology, Diagnosis, and Management of Liver Tumor

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (15 March 2022) | Viewed by 11671

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Dr. Kenya Kamimura

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Guest Editor

1. Department of General Medicine, Niigata University School of Medicine, Niigata, Japan
2. Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Interests: liver tumor; hepatocellular carcinoma; gene therapy; nutrition; liver disease; multi-disciplinary collaboration
Special Issues, Collections and Topics in MDPI journals

Dr. Hiroyuki Abe

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Co-Guest Editor

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 9518510, Japan
Interests: hepatocellular carcinoma; liver fibrosis; liver regeneration; extracellular vesicles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The knowledge and understanding of basic and clinical information for the diagnosis and therapeutic management of liver tumors are essential for physicians to make correct diagnoses and therapeutic decisions. This knowledge contributes to establishing new research plans to develop novel diagnostic markers, methodologies, and therapy. For this purpose, we invite investigators to contribute original research articles, systematic reviews, mini-review articles, and case reports that will stimulate the continuing efforts to understand the basics and clinics of liver tumors and share knowledge for improving patient care. The tumors include benign and malignant liver tumors, such as hepatocellular carcinoma, intrahepatic bile duct cancer, metastatic liver tumor, hepatic lymphomas, hemangioma, focal nodular hyperplasia, adenoma, angiomyolipoma, epithelioid hemangioendothelioma, etc.

Dr. Kenya Kamimura
Dr. Hiroyuki Abe
Guest Editors

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Keywords

Liver tumor
Basic research
Epidemiology
Diagnosis
Therapeutic option

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Published Papers (5 papers)

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Editorial

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3 pages, 185 KiB

Open AccessEditorial

Basics, Epidemiology, Diagnosis, and Management of Liver Tumor

by Hiroyuki Abe and Kenya Kamimura

J. Clin. Med. 2023, 12(2), 524; https://doi.org/10.3390/jcm12020524 - 9 Jan 2023

Viewed by 1378

Abstract

Liver tumors include both benign (non-cancerous) and malignant (cancerous) varieties [...] Full article

(This article belongs to the Special Issue Basics, Epidemiology, Diagnosis, and Management of Liver Tumor)

Research

Jump to: Editorial

11 pages, 2945 KiB

Open AccessArticle

Involvement of DNA Damage Response via the Ccndbp1–Atm–Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis

by Ryoko Horigome, Kenya Kamimura, Yusuke Niwa, Kohei Ogawa, Ken-Ichi Mizuno, Koichi Fujisawa, Naoki Yamamoto, Taro Takami, Tomoyuki Sugano, Akira Sakamaki, Hiroteru Kamimura, Masaaki Takamura and Shuji Terai

J. Clin. Med. 2022, 11(13), 3674; https://doi.org/10.3390/jcm11133674 - 25 Jun 2022

Cited by 1 | Viewed by 2205

Abstract

The dextran sodium sulfate (DSS)-induced colitis mouse model has been widely utilized for human colitis research. While its mechanism involves a response to double-strand deoxyribonucleic acid (DNA) damage, ataxia telangiectasia mutated (Atm)–checkpoint kinase 2 (Chk2) pathway activation related to such response remains unreported. Recently, we reported that cyclin D1-binding protein 1 (Ccndbp1) activates the pathway reflecting DNA damage in its knockout mice. Thus, this study aimed to examine the contribution of Ccndbp1 and the Atm–Chk2 pathway in DSS-induced colitis. We assessed the effect of DSS-induced colitis on colon length, disease activity index, and histological score and on the Atm–Chk2 pathway and the subsequent apoptosis in Ccndbp1-knockout mice. DSS-induced colitis showed distal colon-dominant Atm and Chk2 phosphorylation, increase in TdT-mediated dUTP-biotin nick end labeling and cleaved caspase 3-positive cells, and histological score increase, causing disease activity index elevation and colon length shortening. These changes were significantly ameliorated in Ccndbp1-knockout mice. In conclusion, Ccndbp1 contributed to Atm–Chk2 pathway activation in the DSS-induced colitis mouse model, causing inflammation and apoptosis of mucosal cells in the colon. Full article

(This article belongs to the Special Issue Basics, Epidemiology, Diagnosis, and Management of Liver Tumor)

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9 pages, 915 KiB

Open AccessArticle

CT-Based Prediction of Liver Function and Post-PVE Hypertrophy Using an Artificial Neural Network

by Daniel Heise, Maximilian Schulze-Hagen, Jan Bednarsch, Roman Eickhoff, Andreas Kroh, Philipp Bruners, Simon B. Eickhoff, Ralph Brecheisen, Florian Ulmer and Ulf Peter Neumann

J. Clin. Med. 2021, 10(14), 3079; https://doi.org/10.3390/jcm10143079 - 12 Jul 2021

Cited by 4 | Viewed by 2143

Abstract

Background: This study aimed to evaluate whether hypertrophy after portal vein embolization (PVE) and maximum liver function capacity (LiMAx) are predictable by an artificial neural network (ANN) model based on computed tomography (CT) texture features. Methods: We report a retrospective analysis on 118 patients undergoing preoperative assessment by CT before and after PVE for subsequent extended liver resection due to a malignant tumor at RWTH Aachen University Hospital. The LiMAx test was carried out in a subgroup of 55 patients prior to PVE. Associations between CT texture features and hypertrophy as well as liver function were assessed by a multilayer perceptron ANN model. Results: Liver volumetry showed a median hypertrophy degree of 33.9% (16.5–60.4%) after PVE. Non-response, defined as a hypertrophy grade lower than 25%, was found in 36.5% (43/118) of the cases. The ANN prediction of the hypertrophy response showed a sensitivity of 95.8%, specificity of 44.4% and overall prediction accuracy of 74.6% (p < 0.001). The observed median LiMAx was 327 (248–433) μg/kg/h and was strongly correlated with the predicted LiMAx (R² = 0.89). Conclusion: Our study shows that an ANN model based on CT texture features is able to predict the maximum liver function capacity and may be useful to assess potential hypertrophy after performing PVE. Full article

(This article belongs to the Special Issue Basics, Epidemiology, Diagnosis, and Management of Liver Tumor)

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9 pages, 1690 KiB

Open AccessArticle

Long-Term Effects of Pedicle Clamping during Major Hepatectomy for Colorectal Liver Metastases

by Piotr Krawczyk, Marcin Morawski, Maciej Krasnodębski, Damian Sieńko, Michał Grąt, Philipp Kron and Peter Lodge

J. Clin. Med. 2021, 10(13), 2778; https://doi.org/10.3390/jcm10132778 - 24 Jun 2021

Cited by 3 | Viewed by 1704

Abstract

The use of the Pringle maneuver (PM) varies widely among surgical departments. Its use depends on the operator and type of liver resection. The aim of this study was to determine the impact of the PM on patient outcomes when undergoing major liver resections. This retrospective study comprised 179 colorectal liver metastasis patients from two liver centers from Leeds and Warsaw. Only right or right extended hepatectomies with negative oncological margins were included. The primary outcome measure was the 5-year overall survival (OS). The PM was applied during 60 (33.5%) major hepatectomies included in the study and was associated with a higher peak 3-day postoperative bilirubin concentration (p = 0.002), yet not with the peak 3-day alanine aminotransferase activity (p = 0.415). The 5-year OS after liver resections with the PM and without the PM were 55.0% and 33.4%, respectively (p = 0.019). Following stratification by the Tumor Burden Score, after resections with the use of the PM, superior survival was particularly found in the subgroup of patients at intermediate risk of recurrence (p = 0.004). However, the use of the PM had no significant effect on the 5-year overall survival following adjustment for the confounding effect of the carcinoembryonic antigen concentration (p = 0.265). The use of the PM had no negative effects on the long-term outcomes in patients undergoing major, oncologically radical liver resections for colorectal metastases. Full article

(This article belongs to the Special Issue Basics, Epidemiology, Diagnosis, and Management of Liver Tumor)

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11 pages, 7963 KiB

Open AccessArticle

PEComa—A Rare Liver Tumor

by Marek Krawczyk, Bogna Ziarkiewicz-Wróblewska, Tadeusz Wróblewski, Joanna Podgórska, Jakub Grzybowski, Beata Gierej, Piotr Krawczyk, Paweł Nyckowski, Oskar Kornasiewicz, Waldemar Patkowski, Piotr Remiszewski, Krzysztof Zając and Michał Grąt

J. Clin. Med. 2021, 10(8), 1756; https://doi.org/10.3390/jcm10081756 - 18 Apr 2021

Cited by 16 | Viewed by 3392

Abstract

PEComa (perivascular epithelioid cell tumor) is a rare liver tumor. Decisions regarding patient management are currently based on a few small case series. The aim of this study was to report the clinicopathological features of PEComa in order to provide guidance for management, complemented by our own experience. This retrospective observational study included all patients with PEComa who underwent surgical treatment in two departments between 2002 and 2020. A total of 20 patients were diagnosed with PEComa following histopathological examination. The age of the patients ranged from 21 to 73 years. The majority of patients were women (85%). In most patients, the tumors were incidental. In diagnostic studies, PEComas with high arterial vascularization have been described. Liver resection was the treatment of choice. There was only one postoperative complication. During histopathological evaluation, tumors were composed mostly of epithelioid cells, rarely with spindle cell components, thick-walled vessels, and adipocytes in different proportions. Melanocytic markers (HMB45, MelanA) and at least one smooth muscle marker were expressed in all tumors. Features suggestive of malignancy were found in three cases. In conclusion, PEComa is a rare liver tumor that is usually diagnosed incidentally. In radiological studies, tumors with high arterial vascularization are observed. Liver resection is the treatment of choice. Full article

(This article belongs to the Special Issue Basics, Epidemiology, Diagnosis, and Management of Liver Tumor)

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