Recent Advances in the Diagnosis and Treatment of Gastrointestinal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 766

Special Issue Editor


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Guest Editor
University of Iowa Health Care, 200 Hawkins Dr, Lowa City, IA 52242, USA
Interests: GI disorders; advanced endoscopy; third space endoscopy; colorectal cancer; hepatology disorders
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Special Issue Information

Dear Colleagues,

In recent years, there have been remarkable advances in the diagnosis and treatment of gastrointestinal diseases. These have ranged from physiologic advancements, such as our improved understanding of the pathobiology of inflammatory bowel disease and biologic therapy, to endoscopic advancements that are minimally invasive compared to conventional surgical management. Some examples include endoscopic suturing devices, which are used to close large defects or perforations; peroral endoscopic myotomy POEM for achalasia; endoscopic submucosal dissection and full thickness resection for complex GI lesions and early cancers; and transoral incisionless fundoplication to treat refractory GERD, to name a few.

With this Special Issue, we encourage all types of original research submissions, such as retrospective and prospective studies and review articles that highlight recent advances in the diagnosis and/or treatment of gastrointestinal and hepatology disorders.

Dr. Ahamed Khalyfa
Guest Editor

Manuscript Submission Information

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Keywords

  • advanced endoscopy
  • innovation in GI
  • pathophysiology of GI disorders
  • artificial intelligence in GI
  • gastrointestinal diseases

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Published Papers (1 paper)

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Research

8 pages, 209 KiB  
Article
Endoscopic Resection of Large Non-Pedunculated Colonic Polyps Without Submucosal Injection Is Safe and Effective with Adequate Technique
by Melis Gokce Celdir, Gilles Jadd Hoilat, Alp Serhat Kahveci, Rami El Abiad and Henning Gerke
J. Clin. Med. 2025, 14(2), 642; https://doi.org/10.3390/jcm14020642 - 20 Jan 2025
Viewed by 545
Abstract
Background/Objectives: Endoscopic resection with lift polypectomy using submucosal injection (SI) for large non-pedunculated colorectal polyps is recommended to facilitate complete mucosal resection and decrease the risk of perforation; however, there are no studies comparing the safety and efficacy of large polypectomies with [...] Read more.
Background/Objectives: Endoscopic resection with lift polypectomy using submucosal injection (SI) for large non-pedunculated colorectal polyps is recommended to facilitate complete mucosal resection and decrease the risk of perforation; however, there are no studies comparing the safety and efficacy of large polypectomies with and without lift polypectomy. We aimed to evaluate the feasibility and safety of the polypectomy technique without SI compared to the routine use of SI. Methods: We performed a single tertiary center retrospective study evaluating all consecutive large non-pedunculated colorectal polyps (≥20 mm) referred to expert endoscopists in polypectomy from 2018 through 2021. We collected and analyzed data on demographics, polyp characteristics, resection technique, complications, and polyp recurrence in 6–12 months. Results: In 200 large non-pedunculated colonic polyp resections, 110 (55%) were performed with SI. The median polyp size was slightly larger in SI (30 mm IQR [20, 40] vs. 25 mm IQR [20, 30] in no-SI, p < 0.05), with a range of 20 to 130 mm. There were no differences in delayed bleeding rates. No perforation was noted in the no-SI group, and five perforations occurred in the SI group, without a statistically significant difference between groups. There was no statistically significant difference in the polyp recurrence rate at 6–12 months between the no-SI and SI groups (12% vs. 8% in no-SI vs. SI, respectively, p = 0.48). Conclusions: Complete removal of large non-pedunculated polyps without SI is feasible and safe in this large series. This approach had similar rates of clinically significant post-polypectomy bleeding and a non-significant difference in perforation rate compared to polyp resection with routine use of SI. Randomized trials are warranted to further assess the safety and efficacy of this approach. Full article
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