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New Tools for Predicting Preterm Birth in Asymptomatic High-Risk Women
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New Tools for Predicting Preterm Birth in Asymptomatic High-Risk Women

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: closed (15 September 2021) | Viewed by 10091

Special Issue Editor

Prof. Dr. Liran Hiersch

E-Mail Website
Guest Editor
1. Department of Maternal-Fetal Medicine, Lis Hospital for Women, Sourasksy Medical Center, Tel Aviv, Israel
2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Interests: maternal-fetal medicine; hypertensive disorders of pregnancy; preeclampsia; twins; perinatology; preterm birth
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Preterm birth (PTB) remains one of the biggest challenges in contemporary obstetrics, as it is associated with an increased risk of mortality as well as short- and long-term morbidity of the offspring. Many risk factors for PTB were identified, including multiple gestation, history of PTB, cervical pathology, and uterine factors, among others. As a result, many women are currently classified as being at high risk for PTB, although many of them are asymptomatic prior to delivery. Although extensive research was conducted in this field, the ability of the various available tools to accurately predict PTB remains insufficient. Accurate prediction of PTB is crucial, as it can assist in selecting optimal prevention measurements and counseling regarding the suitable antepartum follow up and the need for potential transfer to the appropriate facility in cases of very high risk of PTB. In contrast, in those found to be at a lower risk, reassurance may relive emotional stress and prevent unnecessary impairment of the daily routine. The present Special Issue aims to deepen the specificity of new tools designed for the prediction of PTB among high-risk women who are asymptomatic. Hopefully, new evidence will increase the knowledge of clinicians and researchers, facilitate collaborations, and improve maternal and neonatal health.

Dr. Liran Hiersch
Guest Editor

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Keywords

  • preterm birth
  • high-risk pregnancy
  • prediction
  • prematurity
  • tools

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Published Papers (2 papers)

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11 pages, 927 KiB  
Article
The Risk of Preterm Birth in Women with Three Consecutive Deliveries—The Effect of Number and Type of Prior Preterm Births
by Liran Hiersch, Yael Pasternak, Nir Melamed, Moshe Meshulam, Reut Shashar, Eran Hadar, Amir Aviram, Yariv Yogev and Eran Ashwal
J. Clin. Med. 2020, 9(12), 3933; https://doi.org/10.3390/jcm9123933 - 4 Dec 2020
Cited by 4 | Viewed by 2019
Abstract
Background: We aimed to explore the association of the number, order, gestational age and type of prior PTB and the risk of preterm birth (PTB) in the third delivery in women who had three consecutive singleton deliveries. Methods: A retrospective cohort study of [...] Read more.
Background: We aimed to explore the association of the number, order, gestational age and type of prior PTB and the risk of preterm birth (PTB) in the third delivery in women who had three consecutive singleton deliveries. Methods: A retrospective cohort study of all women who had three consecutive singleton births at a single medical center over a 20-year period (1994–2013). The primary outcome was PTB (<37 weeks) in the third delivery. Results: 4472 women met inclusion criteria. The rate of PTB in the third delivery was 4.9%. In the adjusted analysis, the risk of PTB was 3.5% in women with no prior PTBs; 10.9% in women with prior one PTB only in the first pregnancy; 16.2% in women with prior one PTB only in the second pregnancy; and 56.5% in women with prior two PTBs. A similar trend was observed when the outcome of interest was spontaneous PTB and when the exposure was limited to prior spontaneous or indicated PTB. Conclusions: In women with a history of PTB, the risk of recurrent PTB in subsequent pregnancies is related to the number and order of prior PTBs. These factors should be taken into account when stratifying the risk of PTB. Full article
(This article belongs to the Special Issue New Tools for Predicting Preterm Birth in Asymptomatic High-Risk Women)
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Review

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14 pages, 298 KiB  
Review
Cervical Assessment for Predicting Preterm Birth—Cervical Length and Beyond
by Lee Reicher, Yuval Fouks and Yariv Yogev
J. Clin. Med. 2021, 10(4), 627; https://doi.org/10.3390/jcm10040627 - 7 Feb 2021
Cited by 20 | Viewed by 7315
Abstract
Preterm birth is considered one of the main etiologies of neonatal death, as well as short- and long-term disability worldwide. A number of pathophysiological processes take place in the final unifying factor of cervical modifications that leads to preterm birth. In women at [...] Read more.
Preterm birth is considered one of the main etiologies of neonatal death, as well as short- and long-term disability worldwide. A number of pathophysiological processes take place in the final unifying factor of cervical modifications that leads to preterm birth. In women at high risk for preterm birth, cervical assessment is commonly used for prediction and further risk stratification. This review outlines the rationale for cervical length screening for preterm birth prediction in different clinical settings within existing and evolving new technologies to assess cervical remodeling. Full article
(This article belongs to the Special Issue New Tools for Predicting Preterm Birth in Asymptomatic High-Risk Women)
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