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Advances in Diagnosis and Treatment of Esophageal Diseases
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Advances in Diagnosis and Treatment of Esophageal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 2762

Special Issue Editor

Dr. Toshiro Iizuka

E-Mail Website
Guest Editor
Cancer and Infectious Disease Center, Komagome Hospital, Tokyo, Japan
Interests: esophageal disease; esophageal cancer; endoscopic submucosal dissection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, there have been remarkable advances in the diagnosis and treatment of esophageal diseases. In malignant diseases, endoscopic diagnosis (diagnosis using image-enhanced endoscopy or AI-assisted diagnosis), endoscopic treatment, robotic surgery, etc., and in benign diseases, techniques such as POEM for esophageal achalasia, diagnosis and treatment of eosinophilic esophagitis, endoscopic treatment of Zenker's diverticulum, or endoscopic resection of esophageal SMT, etc., have been developed. While the level of technical difficulty has increased, there have been advances in the technology and equipment used to overcome these difficulties.

This Special Issue aims to deliver dedicated knowledge on the latest advancements in endoscopic diagnostic methods and therapeutic techniques. Endoscopic innovations in a wide range of fields are particularly welcomed.

Dr. Toshiro Iizuka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • esophageal diseases
  • endoscopic diagnosis
  • POEM
  • achalasia
  • GERD

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Published Papers (2 papers)

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Research

13 pages, 2391 KiB  
Article
Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia
by Tsutomu Kanda, Karen Saiki, Hiroki Kurumi, Akira Yoshida, Yuichiro Ikebuchi, Takuki Sakaguchi, Shigetoshi Urabe, Hitomi Minami, Naoyuki Yamaguchi, Kazuhiko Nakao, Haruhiro Inoue and Hajime Isomoto
J. Clin. Med. 2024, 13(10), 3004; https://doi.org/10.3390/jcm13103004 - 20 May 2024
Viewed by 884
Abstract
Background/Objectives: Esophageal achalasia is an archetypal esophageal motility disorder characterized by abnormal peristalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Methods: In this study, the mRNA expression of docking proteins 1 and 2 (DOK1 and DOK2, respectively) [...] Read more.
Background/Objectives: Esophageal achalasia is an archetypal esophageal motility disorder characterized by abnormal peristalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Methods: In this study, the mRNA expression of docking proteins 1 and 2 (DOK1 and DOK2, respectively) were analyzed and the mechanisms underlying achalasia onset were investigated. Results: DOK1 and DOK2 mRNA levels significantly increased in the LES of patients with achalasia. Moreover, significant correlations were observed between IL-1β and DOK1, IL-1β and DOK2, ATG16L1 and DOK1, and HSV1-miR-H1-3p and DOK2 expression levels. However, a correlation between ATG16L1 and DOK2 or between HSV-miR-H1-3p and DOK1 expression was not observed. In addition, a positive correlation was observed between patient age and DOK1 expression. Microarray analysis revealed a significant decrease in the expression of hsa-miR-377-3p and miR-376a-3p in the LES muscle of patients with achalasia. Conclusions: These miRNAs possessed sequences targeting DOK. The upregulation of DOK1 and DOK2 expression induces IL-1β expression in the LES of achalasia patients, which may contribute to the development of esophageal motility disorder. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Esophageal Diseases)
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11 pages, 2282 KiB  
Article
Upper Esophageal Sphincter Metrics across Eosinophilic Esophagitis, Gastroesophageal Reflux Disease and Functional Dysphagia: A Pilot Study
by Luigi Ruggiero, Paola Iovino, Domenico Gargano, Angela Caloro, Luca De Leo, Antonio D’Antonio, Alessandro Caputo and Antonella Santonicola
J. Clin. Med. 2023, 12(17), 5548; https://doi.org/10.3390/jcm12175548 - 25 Aug 2023
Viewed by 1476
Abstract
Background: Recent studies have evaluated the upper esophageal sphincter (UES) with high-resolution manometry (HRM) in some esophageal diseases, but not eosinophilic esophagitis (EoE). The aim of our study was to evaluate the function of the UES across EoE, gastroesophageal reflux disease (GERD), functional [...] Read more.
Background: Recent studies have evaluated the upper esophageal sphincter (UES) with high-resolution manometry (HRM) in some esophageal diseases, but not eosinophilic esophagitis (EoE). The aim of our study was to evaluate the function of the UES across EoE, gastroesophageal reflux disease (GERD), functional dysphagia (FD), and the relationship with esophageal symptoms, esophageal body contraction, and esophagogastric junction (EGJ) metrics. Methods: HRM was performed on 30 EoE, 18 GERD, and 29 FD patients according to the Chicago Classification 3.0. The study data were exported to the online analysis platform Swallow Gateway. The UES was assessed in terms of UES Resting Pressure (UES-RP), UES Basal Pressure (UES-BP), UES Integrated Relaxation Pressure (UES-IRP), UES Relaxation Time (UES-RT), Basal UES Contractile Integral (Basal UES-CI), Post-Deglutitive UES Contractile Integral (Post-Deglutitive UES-CI), and Proximal Contractile Integral (PCI). Results: ANOVA analysis showed significantly higher values of Post-Deglutitive UES-CI in EoE patients compared with FD patients (p = 0.001). Basal UES-CI and UES-RP showed significantly higher values in EoE (p = 0.002, p = 0.038) and GERD (p < 0.001, p = 0.001) patients compared with FD patients. Correlations between LES-CI and Post-Deglutitive UES-CI, Basal UES-CI, and UES-RP (p ≤ 0.001, p = 0.027, p = 0.017, respectively), and between LES-BP and Post-Deglutitive UES-CI (p = 0.019), independent of diagnosis, were shown. No correlations have been demonstrated between the UES, EGJ metrics, and esophageal symptoms. Conclusions: Some differences in UES metrics in the three different diseases were found. Further studies are needed to confirm the results of our pilot study and possible applications in clinical practice. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Treatment of Esophageal Diseases)
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