Secondary Osteoporosis and Metabolic Bone Diseases
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Orthopedics".
Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 62310
Special Issue Editor
Special Issue Information
Dear Colleagues,
There is ample evidence that patients with various organ dysfunction have an increased risk of bone fragility and fractures. Osteoporosis is not only influenced by low bone volume and mass but also by poor microarchitecture and tissue quality. More emphasis has been given to the quantitative rather than qualitative assessment of bone health, both in primary and secondary osteoporosis. Bone mineral density (BMD) is an incredibly useful clinical tool in assessing bone strength, but it may underestimate the fracture risk in patients with secondary osteoporosis. Serum and urinary bone biomarkers have been found to be reflective of bone activities and predictive of fractures independently of BMD. By utilizing new technologies such as innovative biomarkers and high-resolution images, we can better assess the bone health and fracture risk. Moreover, invasive assessments such as bone histology and micro-indentation are great counterparts.
Various bone medications build up bone mass but also affect tissue quality. Anti-resorptive therapies strikingly reduce bone turnover; however, they can impair bone mineralization and negatively affect the micro-damage repair and causing upsurge bone brittleness. On the other hand, some osteoporosis therapies may cause redistribution of bone structure that may improve bone strength without a noticeable effect on BMD. This may explain why some drugs can affect fracture risk disproportionately to changes in BMD.
This issue focuses on the current and future directions of bone health and management in patients with secondary osteoporosis and various metabolic bone diseases.
Prof. Dr. Amr El-Husseini
Guest Editor
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Keywords
- Osteoporosis
- Metabolic bone disorders
- Fractures
- Bone loss
- Organ dysfunction
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