Clinical Diagnosis and Treatment of Obstructive Sleep Apnea
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".
Deadline for manuscript submissions: closed (25 November 2022) | Viewed by 5390
Special Issue Editor
Special Issue Information
Dear Colleagues,
Obstructive sleep apnea (OSA) is a highly prevalent, chronic respiratory sleep disorder that is estimated to affect 1 billion adults globally. The pathogenesis of OSA depends on an increased anatomical load and on altered physiological traits or endotypes (e.g., elevated loop gain, decreased arousal threshold, reduced pharyngeal muscle responsiveness). Currently, the only available treatment for sleep apnea is continuous positive airway pressure (CPAP). However, CPAP is burdened by numerous side effects and, consequently, poor compliance. Several other alternative treatments have been studied, yet none has provided OSA abolition in the same way that CPAP does. However, this gap in knowledge has progressively been filled with the help of personalized medicine. Pharmacotherapy, hypoglossal nerve stimulation, and mandibular advancement devices have all led to encouraging outcomes when tailored on specific altered OSA endotypes, although these data mainly came from pilot or small sample-sized studies. Nonetheless, the “magic” alternative treatment capable of abolishing sleep apnea regardless of its pathogenic trait (i.e., splinting the upper airway open in a similar fashion to CPAP) is still to be determined.
Dr. Ludovico Messineo
Guest Editor
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Keywords
- sleep apnea
- pharmacotherapy
- respiratory physiology
- ventilation
- COPD
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