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New Advances in Neuro-Oncology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 2728

Special Issue Editors


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Guest Editor
1. Department of Neurosurgery, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA 90089, USA
2. USC Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
Interests: neurological surgery; brain and spine tumors; neuro-oncology; glioblastoma; neuropathology; neuro-radiology; intranasal drug delivery; blood-brain barrier
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Molecular Microbiology & Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Interests: brain cancer; brain metastasis; cancer drug development; blood-brain barrier; molecular and cellular cancer biology; oncogenes; perillyl alcohol; natural compounds; herbal medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tumors of the central nervous system (CNS) encompassing the brain and spinal cord are difficult to treat and often spell poor prognosis for the affected patient. Among the most aggressive CNS tumors are malignant gliomas and CNS-localized metastatic seeds derived from peripheral cancers of the lung, skin, breast, gastrointestinal tract or kidney. Even initially benign brain lesions, such as meningiomas and pituitary adenomas, harbor the potential to progress to an aggressive, life-threatening phenotype. Despite continuous improvements in detection and diagnosis, surgery, radiation treatment, chemotherapies and targeted therapies, and the advent of immune system-targeted interventions, CNS malignancies remain deadly, and too many patients still succumb to these diseases.  

This Special Issue of the Journal of Clinical Medicine on “New Advances in Neuro-Oncology” aims to collect insightful contributions from experts in the field. We invite investigators from around the world to submit original basic science research articles, translational developments, results from clinical studies, and critical review articles that provide up-to-date information and introduce new advances of the entire compendium of neuro-oncology, from experiments at the bench to clinical applications at the bedside.

Prof. Dr. Thomas C. Chen
Dr. Axel H. Schönthal
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • primary brain tumors
  • brain metastases
  • blood–brain barriermolecular mechanisms
  • preclinical models
  • novel therapeutics
  • migration and invasion
  • clinical trials
  • tumor microenvironment
  • tumor stem cells
  • angiogenesis

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Published Papers (1 paper)

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Review

26 pages, 1624 KiB  
Review
Temozolomide, Procarbazine and Nitrosoureas in the Therapy of Malignant Gliomas: Update of Mechanisms, Drug Resistance and Therapeutic Implications
by Bernd Kaina
J. Clin. Med. 2023, 12(23), 7442; https://doi.org/10.3390/jcm12237442 - 30 Nov 2023
Cited by 11 | Viewed by 2240
Abstract
The genotoxic methylating agents temozolomide (TMZ) and procarbazine and the chloroethylating nitrosourea lomustine (CCNU) are part of the standard repertoire in the therapy of malignant gliomas (CNS WHO grade 3 and 4). This review describes the mechanisms of their cytotoxicity and cytostatic activity [...] Read more.
The genotoxic methylating agents temozolomide (TMZ) and procarbazine and the chloroethylating nitrosourea lomustine (CCNU) are part of the standard repertoire in the therapy of malignant gliomas (CNS WHO grade 3 and 4). This review describes the mechanisms of their cytotoxicity and cytostatic activity through apoptosis, necroptosis, drug-induced senescence, and autophagy, interaction of critical damage with radiation-induced lesions, mechanisms of glioblastoma resistance to alkylating agents, including the alkyltransferase MGMT, mismatch repair, DNA double-strand break repair and DNA damage responses, as well as IDH-1 and PARP-1. Cyclin-dependent kinase inhibitors such as regorafenib, synthetic lethality using PARP inhibitors, and alternative therapies including tumor-treating fields (TTF) and CUSP9v3 are discussed in the context of alkylating drug therapy and overcoming glioblastoma chemoresistance. Recent studies have revealed that senescence is the main trait induced by TMZ in glioblastoma cells, exhibiting hereupon the senescence-associated secretory phenotype (SASP). Strategies to eradicate therapy-induced senescence by means of senolytics as well as attenuating SASP by senomorphics are receiving increasing attention, with therapeutic implications to be discussed. Full article
(This article belongs to the Special Issue New Advances in Neuro-Oncology)
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