High-Risk Neuroblastoma: New Clinical Insights and Challenges
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Oncology".
Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 15201
Special Issue Editors
Interests: stem cell transplantation; immunotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroblastoma is the most common extracranial solid tumor in young children, typically presenting at an average age of 1 to 2 years. Occasionally, newborns can present with metastatic neuroblastoma, but adolescents or younger adults can also be affected. In newborns, even disseminated neuroblastoma can spontaneously regress without any therapy, whereas metastasized neuroblastoma in toddlers and older patients is highly agressive and associated with a poor prognosis. Approximately half of the toddlers and older children present with a local tumor (low risk) with a good prognosis and the other half with a disseminated tumor (high risk) and a poor prognosis. These features make neuroblastoma to a tumor with one of the highest spontaneous regression rates on the one side and one of the most aggressive tumors on the other side, due to its tendency to relapse after initial treatment. The biology behind these features begin slowly to be understood, but there are still major challenges, especially in the treatment for the high-risk patients. Current therapy concepts comprise intensive chemotherapy, radiation, autologous or even allogeneic stem cell transplantation, targeted therapies, tumor vaccination approaches, monoclonal antibodies, chimeric antigen receptor (CAR) T-cells, and their combinations.
In this Special Issue, we welcome authors to submit original papers or reviews on current and future new diagnostic and treatment strategies which will hopefully improve the currently poor prognosis of children with high-risk neuroblastoma.
Prof. Dr. Rupert Handgretinger
Prof. Dr. Johannes Hubertus Schulte
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuroblastoma
- autologous stem cell transplantation
- allogeneic stem cell transplantation immunotherapy
- anti-GD2 antibody
- targeted therapy
- CAR T-cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.