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Pain and Rheumatology
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Pain and Rheumatology

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 25803

Special Issue Editors

Prof. Dr. Giustino Varrassi

E-Mail Website
Guest Editor
Fondazione Paolo Procacci, Rome, Italy
Interests: pain medicine; anesthesiology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Piercarlo Sarzi-Puttini

E-Mail Website
Guest Editor
1. School of Medicine, University of Milano, Milan, Italy
2. Rheumatology Unit, Internal Medicine Department, ASST Fatebenefratelli Sacco, Milan, Italy
Interests: pain medicine; pain assessment; pain management; acute pain; chronic pain; pain research; comorbidity; anesthesiology
Prof. Dr. Stefano Coaccioli

E-Mail Website
Guest Editor
Department of Internal Medicine, School of Medicine, Perugia University, Terni, Italy
Interests: pain medicine; rheumatology; clinical immunology; internal medicine

Special Issue Information

Dear Colleagues,

It is our pleasure to present a new “Special Issue” in this journal, whose aim it is to make clear the strong relationship between “Pain” and “Rheumatology”. It would be useless to discuss the epidemiological aspects of this important correlation, which affects a huge quantity of patients all over the world. This Special Issue seeks a new scientific vision on the pathophysiologic aspects of this topic. However, proposals involving basic science and research on the many different aspects of this terrible enemy of humankind are also encouraged. Pain and rheumatology are strictly connected; even the most modern therapies for rheumatic pathologies, which have changed the prognosis of these diseases, are not completely able to prevent or cure the pain they inflict.

This “Special Issue” aims to provide an up-to-date overview of modern discoveries of the inflammatory processes linked to rheumatic diseases, from the molecular scale to the consequences of inflammation. It also hopes to reveal the genetic predispositions for a group of pathologies affecting a large part of the population. Correlations between rheumatic pathologies and other organs/systems (e.g., nervous, cardiovascular, renal, etc.) and their relationship to pain should be highlighted through reports on the last discoveries. The importance of rehabilitation and non-pharmacological treatments, as elucidated by relevant results from scientists around the world, should also be emphasized. This includes any potential interventional treatments for the management of pain in rheumatic diseases. Lastly, submissions should provide a modern vision of pharmacologic therapy, which remains a cornerstone for the wellbeing of the patients affected by rheumatic diseases.

We look forward to receiving your submissions.

Prof. Dr. Giustino Varrassi
Prof. Dr. Piercarlo Sarzi-Puttini
Prof. Dr. Stefano Coaccioli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (3 papers)

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12 pages, 638 KiB  
Article
Recurrence-Free Survival after Synovectomy and Subsequent Radiosynoviorthesis in Patients with Synovitis of the Knee—A Retrospective Data Analysis
by Melanie Schindler, Stephan Puchner, Jan Reinhard, Franziska Leiss, Reinhard Windhager and Richard Lass
J. Clin. Med. 2024, 13(2), 601; https://doi.org/10.3390/jcm13020601 - 21 Jan 2024
Cited by 2 | Viewed by 1709
Abstract
Background: Persistent knee synovitis leads to joint discomfort, incapacitating inflammation, and functional limitations. The conventional approach has involved surgical procedures to eliminate the actively inflamed synovial membrane. This study aims to investigate the recurrence-free survival and functional outcome after synovectomy and subsequent radiosynoviorthesis [...] Read more.
Background: Persistent knee synovitis leads to joint discomfort, incapacitating inflammation, and functional limitations. The conventional approach has involved surgical procedures to eliminate the actively inflamed synovial membrane. This study aims to investigate the recurrence-free survival and functional outcome after synovectomy and subsequent radiosynoviorthesis (RSO) in patients with knee synovitis. Methods: Thirty-seven knees diagnosed with pigmented villonodular synovitis (PVNS), rheumatoid arthritis (RA), and peripheral spondyloarthritis underwent synovectomy and subsequent RSO between May 2005 and October 2016. The mean age was 34.9 ± 15.1 years, and the mean follow-up period was 84 ± 36.4 months. Clinical outcomes were assessed using the Oxford Knee Score and the presence of swelling and pain at the last follow-up. Recurrence-free survival denotes the duration from synovectomy to surgical re-synovectomy. Results: In general, twelve knees underwent re-synovectomy after a mean follow-up of 34.8 ± 24.9 months. The recurrence-free survival was 83.8% at two years, 71.3% at five years, and 61.7% at ten years. The subgroup analysis revealed recurrence-free survival at two years in 63.6% of patients with PVNS, 86.7% of those with RA, and 100% of individuals with peripheral spondyloarthritis. Conclusions: This study demonstrates that combined therapy for synovitis is an effective approach, significantly improving clinical outcomes. Full article
(This article belongs to the Special Issue Pain and Rheumatology)
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Review

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27 pages, 3755 KiB  
Review
The Prevalence of Pain in Chronic Diseases: An Umbrella Review of Systematic Reviews
by Dmitriy Viderman, Karina Tapinova, Mina Aubakirova and Yerkin G. Abdildin
J. Clin. Med. 2023, 12(23), 7302; https://doi.org/10.3390/jcm12237302 - 25 Nov 2023
Cited by 4 | Viewed by 2803
Abstract
Since pain is common in many diseases, it is important to summarize the precise prevalence data on pain and high-impact pain, which frequently worsens the quality of life and work activities. This umbrella review aims to estimate the prevalence of pain among patients [...] Read more.
Since pain is common in many diseases, it is important to summarize the precise prevalence data on pain and high-impact pain, which frequently worsens the quality of life and work activities. This umbrella review aims to estimate the prevalence of pain among patients with different chronic diseases/conditions. We followed the PRISMA guidelines. We identified the following areas addressing the prevalence of pain: (1) pain in cancer patients; (2) neurodegenerative diseases; (3) chronic heart failure; (4) chronic obstructive pulmonary disease; (5) chronic kidney diseases; (6) liver diseases and failure; (7) nursing home seniors; and (8) postamputation (phantom) pain. We included systematic reviews and meta-analyses that reported pain in patients from the mentioned populations. The prevalence of pain in chronic diseases is high, in some cases even higher than the cardinal symptoms of these diseases/conditions. Most patients who suffer from any of these diseases/conditions can develop chronic pain at later stages. Pain in chronic diseases does not receive enough attention and is not properly managed. Future studies are warranted to establish a more precise prevalence of chronic pain and develop better methods of pain screening, detection, and management. Full article
(This article belongs to the Special Issue Pain and Rheumatology)
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12 pages, 1058 KiB  
Review
Osteoarthritis: New Insight on Its Pathophysiology
by Stefano Coaccioli, Piercarlo Sarzi-Puttini, Panagiotis Zis, Giuseppe Rinonapoli and Giustino Varrassi
J. Clin. Med. 2022, 11(20), 6013; https://doi.org/10.3390/jcm11206013 - 12 Oct 2022
Cited by 75 | Viewed by 20099
Abstract
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements in recent years. It has been observed that cartilage degeneration is preceded by subchondral bone lesions, suggesting a key role of this mechanism within the pathogenesis and progression of OA, as [...] Read more.
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements in recent years. It has been observed that cartilage degeneration is preceded by subchondral bone lesions, suggesting a key role of this mechanism within the pathogenesis and progression of OA, as well as the formation of ectopic bone and osteophytes. Moreover, low-grade, chronic inflammation of the synovial lining has gained a central role in the definition of OA physiopathology, and central immunological mechanisms, innate but also adaptive, are now considered crucial in driving inflammation and tissue destruction. In addition, the role of neuroinflammation and central sensitization mechanisms as underlying causes of pain chronicity has been characterized. This has led to a renewed definition of OA, which is now intended as a complex multifactorial joint pathology caused by inflammatory and metabolic factors underlying joint damage. Since this evidence can directly affect the definition of the correct therapeutic approach to OA, an improved understanding of these pathophysiological mechanisms is fundamental. To this aim, this review provides an overview of the most updated evidence on OA pathogenesis; it presents the most recent insights on the pathophysiology of OA, describing the interplay between immunological and biochemical mechanisms proposed to drive inflammation and tissue destruction, as well as central sensitization mechanisms. Moreover, although the therapeutic implications consequent to the renewed definition of OA are beyond this review scope, some suggestions for intervention have been addressed. Full article
(This article belongs to the Special Issue Pain and Rheumatology)
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