Nanoparticles and Medical Imaging for Image Guided Medicine

Special Issue Editor


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Guest Editor
Department of Radiology, Northwestern University Feinberg, School of Medicine, Chicago, IL 60611, USA
Interests: multimodal medical imaging; translational nano cancer therapeutics; MRI contrast agent; nanotechnology; biomaterials; image guided cancer therapy; organic/inorganic/metal nano materials for medicine; cancer treatment; multifunctional nanoplatform; thermo-responsive polymer; magnetic hybrid nanoparticles; targeted drug/contrast agents
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Special Issue Information

Dear Colleagues,

Image-guided medicine is rapidly growing to improve treatment regimens as advancing medical imaging, including magnetic resonance imaging (MRI), computed tomography (CT), radiography, ultrasound, positron emission tomography (PET), and single photon emission computed tomography (SPECT). A combination of modern nanoplatforms with high performance in imaging and therapeutics may be critical to improve medical outcomes. One of emerging fields is the image guided therapy using various nanoparticles. Those are including basic bench, preclinical in vitro/in vivo and clinical researches combining synthesis of multimodal nanoparticle and tracking/navigation tools to improve accuracy and outcomes of the therapeutics. Most of the emerging interventional technique such as heat activated targeted drug delivery, image guided ablation (microwave or HIFU), percutaneous injection gene/bacteria therapy, transcatheter treatments for tumor specific local therapy, serial biopsy, thrombolytic therapy, and so on, can be combined with nanotechnology in clinic. Careful design/selection/synthesis of multifunctional imaging/therapeutic nanomaterials with therapeutic agents will be critical for the translational optimization these new image guided medicine techniques.

The intent of this Special Issue is to collect cutting-edge image-guided nanomedicine technology of leading scientists for providing a new opportunity and perspectives of the nanotechnology.

This Special Issue is intended to cover the following topics, but is not limited to them:

  1. Multifunctional Imaging and Therapeutic Micro/Nano Carriers
  2. New Interventional Approaches using nanomaterials
  3. Smart Nanomaterials for Biomedical Applications
  4. Noble metallic nanoparticles for Image Guided Medicine
  5. Magnetic Nanoparticles Mediated Local Image Guided Therapy
  6. Multifunctional Drug Delivery Carriers
  7. Nano Radiosensitizers for Brachytherapy
  8. Stimuli Responsive Polymeric Materials for Photodynamic/Photothermal Ablation

Any works concerning the imaging and nano for medical application, as well the development of new image-guided medicine approaches for the treatment of diseases, will be within the scope of this Special Issue. All submitted papers must present novel results, or the advancement of previously published data, and the matter should be dealt with scientific rigor.

Assist. Prof. Dong-Hyun Kim
Guest Editor

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Keywords

  • Image guided therapy
  • Multimodal Medical Imaging
  • Translational Nano cancer therapeutics
  • Medical Imaging Contrast Agent
  • Nanotechnology
  • Organic/Inorganic/Metal Nano materials for Medicine
  • Cancer Treatment
  • Multifunctional Nano Platform
  • Thermo-responsive Polymer
  • Magnetic Hybrid Nanoparticles
  • Targeted Local Immuno-therapy

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Published Papers (2 papers)

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Research

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759 KiB  
Article
Towards a Novel Approach for Tumor Volume Quantification
by Amina Kharbach, Benaissa Bellach, Mohammed Rahmoune, Mohammed Rahmoun and Hanane Hadj Kacem
J. Imaging 2017, 3(4), 41; https://doi.org/10.3390/jimaging3040041 - 27 Sep 2017
Cited by 1 | Viewed by 3917
Abstract
In medical image processing, evaluating the variations of lesion volume plays a major role in many medical applications. It helps radiologists to follow-up with patients and examine the effects of therapy. Several approaches have been proposed to meet with medical expectations. The present [...] Read more.
In medical image processing, evaluating the variations of lesion volume plays a major role in many medical applications. It helps radiologists to follow-up with patients and examine the effects of therapy. Several approaches have been proposed to meet with medical expectations. The present work comes within this context. We present a new approach based on the local dissimilarity volume (LDV) that is a 3D representation of the local dissimilarity map (LDM). This map presents a useful means to compare two images, offering a localization of information. We proved the effectiveness of this method (LDV) compared to medical techniques used by radiologists. The result of simulations shows that we can quantify lesion volume by using the LDV method, which is an efficient way to calculate and localize the volume variation of anomalies. It allowed a time savings with the compete satisfaction of an expert during the medical treatment. Full article
(This article belongs to the Special Issue Nanoparticles and Medical Imaging for Image Guided Medicine)
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Review

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7 pages, 613 KiB  
Review
Image-Guided Cancer Nanomedicine
by Dong-Hyun Kim
J. Imaging 2018, 4(1), 18; https://doi.org/10.3390/jimaging4010018 - 11 Jan 2018
Cited by 31 | Viewed by 7480
Abstract
Multifunctional nanoparticles with superior imaging properties and therapeutic effects have been extensively developed for the nanomedicine. However, tumor-intrinsic barriers and tumor heterogeneity have resulted in low in vivo therapeutic efficacy. The poor in vivo targeting efficiency in passive and active targeting of nano-therapeutics [...] Read more.
Multifunctional nanoparticles with superior imaging properties and therapeutic effects have been extensively developed for the nanomedicine. However, tumor-intrinsic barriers and tumor heterogeneity have resulted in low in vivo therapeutic efficacy. The poor in vivo targeting efficiency in passive and active targeting of nano-therapeutics along with the toxicity of nanoparticles has been a major problem in nanomedicine. Recently, image-guided nanomedicine, which can deliver nanoparticles locally using non-invasive imaging and interventional oncology techniques, has been paid attention as a new opportunity of nanomedicine. This short review will discuss the existing challenges in nanomedicine and describe the prospects for future image-guided nanomedicine. Full article
(This article belongs to the Special Issue Nanoparticles and Medical Imaging for Image Guided Medicine)
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