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Epidemiology of Invasive Mycosis in the Hospital
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Epidemiology of Invasive Mycosis in the Hospital

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 7 April 2025 | Viewed by 1423

Special Issue Editor

Dr. Giuliana Lo Cascio

E-Mail Website
Guest Editor
1. Microbiology and Clinical Microbiology, Department of Medicine and Surgery, University of Parma
2.Microbiology Unit, Director of the Clinical Pathology Department, Hospital of Piacenza
Interests: pathology; diagnostics; infectious diseases; clinical microbiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungal pathogens and infections are increasing all over the world and emerging as a global public health concern. Patients who develop invasive fungal infections generally have host defense impairment due to different reasons, including underlying health problems or a weakened immune system due to chronic lung disease, prior tuberculosis (TB), HIV, cancer, diabetes mellitus, or being critically ill in an intensive care unit; however, the at-risk population continues to grow due to many factors, including advancements in modern medicine and accessibility to therapies as well as interventions that impair the immune system, such as chemotherapy and immunotherapy for cancer, in addition to solid organ transplantation.

New groups at risk of IFD are constantly being identified, as was demonstrated by our global COVID-19 pandemic experience, in the same way that new pathogenic fungi are continuously being reported and new epidemiological landscapes are possible around the world.

In this Special Issue, we will collect research on the actual global scenario of the epidemiology of invasive fungal disease related to different at-risk populations or related to specific local outbreaks in the hospital.

Dr. Giuliana Lo Cascio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal pathogen 
  • invasive fungal disease
  • epidemiology

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Published Papers (1 paper)

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Research

13 pages, 2243 KiB  
Article
The Association of Chronic Pulmonary Aspergillosis and Chronic Pulmonary Histoplasmosis with MDR-TB Patients in Indonesia
by Noni N. Soeroso, Lambok Siahaan, Selfi Khairunnisa, Raden Ajeng Henny Anggriani, Aida Aida, Putri C. Eyanoer, Elvita R. Daulay, Erlina Burhan, Anna Rozaliyani, Ronny Ronny, Robiatul Adawiyah, David W. Denning and Retno Wahyuningsih
J. Fungi 2024, 10(8), 529; https://doi.org/10.3390/jof10080529 - 29 Jul 2024
Viewed by 1261
Abstract
In Indonesia, 2.4% of all new tuberculosis patients had multi-drug resistant disease (MDR-TB); an estimated 24,000 incidences. Historical case series of MDR-TB described a high frequency of cavitation and poor prognosis. The diagnosis of chronic pulmonary aspergillosis (CPA) relies on raised levels of [...] Read more.
In Indonesia, 2.4% of all new tuberculosis patients had multi-drug resistant disease (MDR-TB); an estimated 24,000 incidences. Historical case series of MDR-TB described a high frequency of cavitation and poor prognosis. The diagnosis of chronic pulmonary aspergillosis (CPA) relies on raised levels of Aspergillus IgG antibodies, and detectable Histoplasma IgG antibodies are suspicious for chronic pulmonary histoplasmosis (CPH). We investigated whether MDR-TB patients might have concurrent CPH or CPA. This was a cross-sectional study with 50 MDR-TB patients. ELISA was used to detect Histoplasma IgG antibodies and lateral flow assay was used to detect Aspergillus IgG/IgM antibodies. Several other possible disease determinants were assessed by multivariate analysis. Of the 50 MDR-TB patients, 14 (28%) and 16 (32%) had positive Histoplasma or Aspergillus serology; six patients (12%) had dual antibody reactivity. Radiological abnormalities in positive patients included diffuse or local infiltrates, nodules, consolidation, and apical cavities, consistent with CPH and CPA. Patients with detectable fungal antibodies tended to have worse disease, and 4 of 26 (15.3%) died in the first 5 months of dual infection (p = 0.11 compared with no deaths in those with only MDR-TB). The criteria for the diagnosis of CPH and CPA were fulfilled in those with moderately and far advanced disease (13 of 14 or 93%) and 12 of 16 (75%), respectively. Damp housing was the only determinant associated with Histoplasma antibodies (PR 2.01; 95%CI 0.56–7.19), while pets were associated with the Aspergillus antibody (PR 18.024; 95%CI 1.594–203.744). CPA or CPH are probably frequent in MDR-TB patients in Indonesia and may carry a worse prognosis. Full article
(This article belongs to the Special Issue Epidemiology of Invasive Mycosis in the Hospital)
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