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New Discovery on Antifungal Drugs
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New Discovery on Antifungal Drugs

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 5609

Special Issue Editor

Dr. Erico Silva De Loreto

E-Mail Website
Guest Editor
Sobresp Faculty of Health Sciences, Santa Maria, RS, Brazil
Interests: antifungal susceptibility; fungal identification methods; Pythium insidiosum; experimental models of infections

Special Issue Information

Dear Colleagues,

The Journal of Fungi is announcing a Special Issue dedicated to "New Discoveries on Antifungal Drugs", as the rising incidence of fungal infections and increasing resistance to existing treatments, such as the emerging forms of Candida auris that are multiresistant to antifungal drugs, demand innovative approaches. This Special Issue will feature research and review manuscripts on recent advances in antifungal drugs and strategies. These include introducing novel antifungal drugs, strategies employing combination therapy to overcome fungal resistance, and the potential for repurposing drugs with antifungal activity against pathogenic fungi. Furthermore, we invite submissions investigating the challenges associated with fungal resistance and novel techniques developed for evaluating the susceptibility of pathogenic fungi. Understanding the mechanisms of antifungal resistance is also within the scope of this Special Issue. Together, these contributions will provide crucial insights into innovative strategies for overcoming resistance and novel methods for evaluating fungal susceptibility, thereby addressing the growing threat of antifungal resistance.

Dr. Erico Silva De Loreto
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antifungal resistance mechanisms
  • combination therapy
  • drug repurposing
  • emerging resistance
  • fungal susceptibility
  • novel antifungal drugs

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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13 pages, 1219 KiB  
Article
Characterization of a New Hsp110 Inhibitor as a Potential Antifungal
by Cancan Sun, Yi Li, Justin M. Kidd, Jizhong Han, Liangliang Ding, Aaron E. May, Lei Zhou and Qinglian Liu
J. Fungi 2024, 10(11), 732; https://doi.org/10.3390/jof10110732 - 23 Oct 2024
Cited by 1 | Viewed by 994
Abstract
Fungal infections present a significant global health challenge, prompting ongoing research to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are molecular chaperones essential for maintaining cellular protein homeostasis in eukaryotes. Fungal Hsp110s have emerged as a promising target for [...] Read more.
Fungal infections present a significant global health challenge, prompting ongoing research to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are molecular chaperones essential for maintaining cellular protein homeostasis in eukaryotes. Fungal Hsp110s have emerged as a promising target for innovative antifungal strategies. Notably, 2H stands out as a promising candidate in the endeavor to target Hsp110s and combat fungal infections. Our study reveals that 2H exhibits broad-spectrum antifungal activity, effectively disrupting the in vitro chaperone activity of Hsp110 from Candida auris and inhibiting the growth of Cryptococcus neoformans. Pharmacokinetic analysis indicates that oral administration of 2H may offer enhanced efficacy compared to intravenous delivery, emphasizing the importance of optimizing the AUC/MIC ratio for advancing its clinical therapy. Full article
(This article belongs to the Special Issue New Discovery on Antifungal Drugs)
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8 pages, 520 KiB  
Communication
Antifungal Activity of Tea Tree (Melaleuca alternifolia Cheel) Essential Oils against the Main Onychomycosis-Causing Dermatophytes
by Esther Mingorance Álvarez, Julia Villar Rodríguez, Olga López Ripado and Raquel Mayordomo
J. Fungi 2024, 10(10), 675; https://doi.org/10.3390/jof10100675 - 27 Sep 2024
Viewed by 2243
Abstract
Onychomycosis is a common fungal infection that affects the nails and accounts for approximately 50% of all nail diseases. The main pathogens involved include dermatophytes, such as Trichophyton rubrum, members of the T. mentagrophytes complex, and emerging pathogens in this infection, T. [...] Read more.
Onychomycosis is a common fungal infection that affects the nails and accounts for approximately 50% of all nail diseases. The main pathogens involved include dermatophytes, such as Trichophyton rubrum, members of the T. mentagrophytes complex, and emerging pathogens in this infection, T. schoenleinii and T. tonsurans. Tea tree (Melaleuca alternifolia Cheel) essential oil (EO) has been proposed as a promising natural alternative to traditional treatments due to its antimicrobial properties. Among its more than 100 compounds, terpinen-4-ol is one of the main contributors to the antifungal action of this EO. To determine the antifungal activity of tea tree EO against dermatophytes, we designed an in vitro study using EUCAST-AFST protocols to obtain the values of MIC (minimum inhibitory concentration) and MFC (minimum fungicidal concentration) of several commercial M. alternifolia Cheel EOs against three species of dermatophytes isolated from clinical samples with suspected toenail onychomycosis. The results showed that the microorganism most sensitive to the action of the EO was T. rubrum, which had an MIC value more than 13 times lower than the value obtained for T. schoenleinii (0.4% v/v), the most resistant isolate. No differences in antifungal activity were observed by the analysed EOs or between the MIC and MFC values. These in vitro results suggest that tea tree EO is a viable option for the alternative treatment of onychomycosis, although clinical studies are needed to confirm the long-term antifungal activity, safety and efficacy of the oils studied in a clinical context. Full article
(This article belongs to the Special Issue New Discovery on Antifungal Drugs)
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Review

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21 pages, 3357 KiB  
Review
Treating Pythiosis with Antibacterial Drugs Targeting Protein Synthesis: An Overview
by Erico S. Loreto, Juliana S. M. Tondolo and Régis A. Zanette
J. Fungi 2024, 10(4), 234; https://doi.org/10.3390/jof10040234 - 22 Mar 2024
Cited by 1 | Viewed by 1828
Abstract
This review article explores the effectiveness of antibacterial drugs that inhibit protein synthesis in treating pythiosis, a difficult-to-treat infection caused by Pythium insidiosum. The article highlights the susceptibility of P. insidiosum to antibacterial drugs, such as macrolides, oxazolidinones, and tetracyclines. We examine [...] Read more.
This review article explores the effectiveness of antibacterial drugs that inhibit protein synthesis in treating pythiosis, a difficult-to-treat infection caused by Pythium insidiosum. The article highlights the susceptibility of P. insidiosum to antibacterial drugs, such as macrolides, oxazolidinones, and tetracyclines. We examine various studies, including in vitro tests, experimental infection models, and clinical case reports. Based on our synthesis of these findings, we highlight the potential of these drugs in managing pythiosis, primarily when combined with surgical interventions. The review emphasizes the need for personalized treatment strategies and further research to establish standardized testing protocols and optimize therapeutic approaches. Full article
(This article belongs to the Special Issue New Discovery on Antifungal Drugs)
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